Measuring carbon monoxide effect with trace metals.
Department of Human Ecology and Environmental Health, Health Sciences Center, Oklahoma City, Oklahoma, Terminal Progress Report, 1973 Dec; :1-10
Rats are exposed to 25, 50, 100 and 200ppm carbon-monoxide (630080) for up to 15 weeks and magnesium (7439954), manganese (7439965), zinc (7440666), copper (7440508), and iron (7439896) content in blood, lungs, heart, brain, liver, kidney, spleen, testes and thymus is used as indicator of the effect of the gas. Cadmium (7440439) and chromium (7440473) analyses are conducted on selected tissues. Results show that metals can be employed as an index of metabolic alteration produced by carbon-monoxide. Involvement of carbon- monoxide with host defense mechanisms, enhancement of phagocytic activity of macrophages, an increased antibody titer, and induced blood fibrinolytic activity are also demonstrated after the inhalation of carbon-monoxide.
NIOSH-Grant; Toxic-gases; Trace-elements; Metals; Physiological-effects; Metabolic-disorders
Human Ecology and Environ Hlth Univ of Oklahoma Med Ctr 800 N E 13Th Street Oklahoma City, Okla 73104
630-08-0; 7439-95-4; 7439-96-5; 7440-66-6; 7440-50-8; 7439-89-6; 7440-43-9; 7440-47-3
Final Grant Report
Department of Human Ecology and Environmental Health, Health Sciences Center, Oklahoma City, Oklahoma, Terminal Progress Report No. R01-OH-00330, 10 pages, 10 references
University of Oklahoma Hlth Sciences Ctr, Oklahoma City, Oklahoma