Decarboxylation of DL-DOPA studied by C-14O2 analysis in Parkinsonian and manganic patients.
Mena-I; Horiuchi-KZ; Court-J; Lopez-G
Dynamic Studies with Radioisotopes in Medicine 1974: Proceedings of a Symposium on Dynamic Studies with Radioisotopes in Clinical Medicine and Research, Knoxville, Tennessee, July 15-19, 1974. Vienna: International Atomic Energy Agency, 1975 May; 2:483-488
The total body decarboxylation rate of intravenously injected DL- dopa C-14 and L-tyrosine C-14 is determined by continuous measurement of exhaled radioactive carbon-dioxide (124389) in Parkinsonian and manganic patients, healthy manganese miners (7439965) and controls. The radioactivity is found to reach a maximum at 5-10 minutes and is followed by an exponential drop. At 24 hours after injection no further exhalation of radioactive carbon- dioxide is detected. The differences among the groups are not significant, but reduction by alpha-methyldopa (MK-486) is significant for all groups. When labeled L-tyrosine is injected less radioactive carbon-dioxide is exhaled. No significant differences are observed among the four groups and no blocking effects of MK-485 are evident. Results show that extracerebral dopa decarboxylase is not probably poisoned by manganese.
NIOSH-Grant; Neurotoxic-effects; Neuromotor-disorders; Metallic-poisoning; Manganese-poisoning; Amino-acids; Radioactive-substances; Toxic-gases
Nuclear Medicine Pan American Hlth Organization 525 23Rd Street, N W Washington, D C 20037
Neurotoxic Disorders; Neurotoxic-effects
Dynamic Studies with Radioisotopes in Medicine 1974: Proceedings of a Symposium on Dynamic Studies with Radioisotopes in Clinical Medicine and Research, Knoxville, Tennessee, July 15-19, 1974
Pan American Health Organization, Washington, Dist of Col