Carbon monoxide exposure in rabbits: enhanced blood fibrinolytic activity inhibited by epsilon amino caproic acid.
Kalmaz-EV; Nau-C; Coleman-R; Joel-W; Canter-L; Cobb-JK; Hampton-JW
NIOSH 1975 Mar; :1-25
Part of a series entitled "Carbon Monoxide Induced Fibrinolysis", reporting the inhibition of enhanced blood fibrinolytic activity by epsilon amino caproic-acid (60322) (EACA) in rabbits exposed to carbon-monoxide. Fibrinolysis tests show acceleration of the whole blood clot lysis and euglobulin lysis times. A fibrin plate test confirms the increased lysis and serum fibrin-fibrinogen degradation products are elevated in the exposed animals, but administration of EACA inhibits the lysis. Alpha-1-antitrypsin and alpha-2- macroglobulin assays in experimental and control groups show no change. Microscopic examination of the large vessels shows endothelial damage which indicates a possible source for a plasminogen activator release.
NIOSH-Grant; Toxic-gases; Air-contamination; Blood-poisoning; Bioassays; Amino-acids
Human Ecology and Environ Hlth Univ of Oklahoma Med Ctr 800 N E 13Th Street Oklahoma City, Okla 73104
Final Grant Report
National Institute for Occupational Safety and Health
University of Oklahoma Hlth Sciences Ctr, Oklahoma City, Oklahoma