Changes in pulmonary function in workers exposed to vinyl chloride and polyvinyl chloride.
Miller-A; Teirstein-AS; Chuang-M; Selikoff-IJ; Warshaw-R
Ann NY Acad Sci 1975 Jan; 246:42-52
Spirometry and maximum expiratory flow-volume curves are obtained in 348 workers in a vinyl-chloride (75014) polymerization plant to determine whether occupational exposure to vinyl-chloride gas and polyvinyl-chloride (9002862) dust is associated with changes in pulmonary function. The major finding is diminution in air flow in 200 workers (57.5 per cent), an abnormality correlated with age and duration of exposure. A relationship with smoking is noted only in younger workers with exposures of less than 10 years. When age exceeds 40 years or exposure 20 years, prevalence of this impairment is similar in smokers and nonsmokers, suggesting that occupational or other environmental factors are operative.
NIOSH-Publication; NIOSH-Grant; Pulmonary-system-disorders; Chlorinated-hydrocarbons; Toxic-gases; Smoking-habits; Epidemiology; Plastics-industry; Polymers
Community Medicine Mount Sinai School of Medicine Fifth Avenue and 100 Street New York, N Y 10029
Annals of the New York Academy of Sciences
Mount Sinai School of Medicine, New York, New York