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Prostaglandin regulation of airway smooth muscle tone.
Orehek-J; Douglas-JS; Lewis-AJ; Bouhuys-A
Nature, New Biology 1973 Sep; 245(142):84-85
In-vitro experiments indicate that the tone of the isolated guinea- pig trachea is modulated by the prostaglandins released subsequent to injection of histamine (51456) and acetylcholine (51843), if the prostaglandins (11000263) reach the airway smooth muscle. To prevent prostaglandin interference when assessing the effects of contractile agents, the tracheal strips required treatment with prostaglandin synthesis inhibitors, including aspirin (50782) and indomethacin (53861).
NIOSH-Publication; NIOSH-Grant; Respiratory-functions; Muscle-functions; Muscle-tone; Respiratory-system; Muscle-relaxants; Muscle-contractions; Pharmacology; Drugs; Analgesics
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Issue of Publication
Nature, New Biology
John B. Pierce Foundation of Connecticut Inc, New Haven, Connecticut,
Page last reviewed: March 11, 2019
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