NIOSHTIC-2 Publications Search
Prostaglandin regulation of airway smooth muscle tone.
Orehek-J; Douglas-JS; Lewis-AJ; Bouhuys-A
Nature, New Biology 1973 Sep; 245(142):84-85
In-vitro experiments indicate that the tone of the isolated guinea- pig trachea is modulated by the prostaglandins released subsequent to injection of histamine (51456) and acetylcholine (51843), if the prostaglandins (11000263) reach the airway smooth muscle. To prevent prostaglandin interference when assessing the effects of contractile agents, the tracheal strips required treatment with prostaglandin synthesis inhibitors, including aspirin (50782) and indomethacin (53861).
NIOSH-Publication; NIOSH-Grant; Respiratory-functions; Muscle-functions; Muscle-tone; Respiratory-system; Muscle-relaxants; Muscle-contractions; Pharmacology; Drugs; Analgesics
John B Pierce Fdn Lab John B Pierce Fdn Lab 290 Congress Avenue New Haven, Conn 06519
51-45-6; 51-84-3; 11000-26-3; 50-78-2; 53-86-1
Issue of Publication
Nature, New Biology
John B. Pierce Foundation of Connecticut Inc, New Haven, Connecticut,
Page last reviewed: April 12, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division