In vitro histamine release from human lung as a model for the acute response to cotton dust.
Ann NY Acad Sci 1974 Feb; 221(1):124-131
An in vitro system for the acute response in byssinosis due to cotton dust confirms the conclusion from in vivo observations that the dust contains a pharmacological agent capable of releasing histamine, with data suggesting that the same mechanism is responsible for histamine (51456) release and bronchoconstriction. Methyl piperonylate is suggested as the cotton bract component responsible. The presence of a pharmacological agent in cotton dust does not explain the etiology of chronic byssinosis, since reversible bronchoconstriction follows exposure to dust by healthy workers without byssinosis. However, epidemiological studies show that persons who respond acutely to cotton dust are likely to develop chronic byssinosis. Thus the acute reversible bronchoconstriction in response to cotton dust may be useful in predicting individual susceptibility to chronic byssinosis.
NIOSH-Publication; NIOSH-Grant; Respiratory-system-disorders; Respiratory-mechanics; Allergic-reactions; Sensitization; Biochemical-reactions
John B Pierce Fdn Lab John B Pierce Fdn Lab 290 Congress Avenue New Haven, Conn 06519
Annals of the New York Academy of Sciences
John B Pierce Fdn of Conn Inc, New Haven, Connecticut