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Manganese poisoning: a metabolic disorder.
Pan American Health Organization, Final Report, 1974 Jan; :1-28
Study of the clinical and metabolic aspects of manganese (7439965) poisoning. Findings include: levodopa is capable of correcting symptoms of extrapyramidal damage induced by manganese; susceptibility to manganese poisoning is linked to increased intestinal absorption of manganese in anemic individuals, with a positive correlation demonstrated for iron and manganese absorption; parallel pathophysiology is found between manganese poisoning and Parkinson's disease. Other areas of investigation include: long term treatment of manganic patients, mechanism for intermittent loss of control and involuntary movements induced by levodopa, and study of interaction of manganese and dopa and permeability of blood brain barrier to manganese.
NIOSH-Grant; Physiological-effects; Biochemical-reactions; Metal-poisoning; Transition-metals; Metabolism; Drug-therapy
Nuclear Medicine Pan American Hlth Organization 525 23Rd Street, N W Washington, D C 20037
Final Grant Report
NTIS Accession No.
Pan American Health Organization, Final Report, 28 pages, 16 references
Pan American Health Organization, Washington, Dist of Col
Page last reviewed: April 12, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division