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Manganese poisoning: a metabolic disorder.

Authors
Mena-I
Source
Pan American Health Organization, Final Report, 1974 Jan; :1-28
Link
NIOSHTIC No.
00036285
Abstract
Study of the clinical and metabolic aspects of manganese (7439965) poisoning. Findings include: levodopa is capable of correcting symptoms of extrapyramidal damage induced by manganese; susceptibility to manganese poisoning is linked to increased intestinal absorption of manganese in anemic individuals, with a positive correlation demonstrated for iron and manganese absorption; parallel pathophysiology is found between manganese poisoning and Parkinson's disease. Other areas of investigation include: long term treatment of manganic patients, mechanism for intermittent loss of control and involuntary movements induced by levodopa, and study of interaction of manganese and dopa and permeability of blood brain barrier to manganese.
Keywords
NIOSH-Grant; Physiological-effects; Biochemical-reactions; Metal-poisoning; Transition-metals; Metabolism; Drug-therapy
Contact
Nuclear Medicine Pan American Hlth Organization 525 23Rd Street, N W Washington, D C 20037
CAS No.
7439-96-5
Publication Date
19740101
Document Type
Final Grant Report
Funding Amount
239133
Funding Type
Grant
Fiscal Year
1974
NTIS Accession No.
PB90-115106
NTIS Price
A03
Identifying No.
Grant-Number-R01-OH-00313
NIOSH Division
OEP
Source Name
Pan American Health Organization, Final Report, 28 pages, 16 references
State
DC
Performing Organization
Pan American Health Organization, Washington, Dist of Col
Page last reviewed: May 5, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division