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Alterations in hepatocytes after manipulation of the diet: copper, zinc and cadmium interactions.
Miller-ML; Murthy-L; Basom-CR; Petering-HG
Am J Anat 1974 Sep; 141(1):23-39
Morphometric analyses of liver parenchymal cells are performed on ale albino rats fed a semipurified diet supplemented with two levels of copper (7440508) and zinc (7440666). The metals are administered in demineralized drinking water to four groups of animals at two levels. Cadmium (7440439) is also administered in the drinking water daily to one group of rats. Hepatocytes from rats fed the semipurified diet with low copper and zinc plus cadmium show a significant increase in smooth endoplasmic reticulum compared to animals fed the semipurified diet alone. Smooth endoplasmic reticulum increases when diets include chow and cadmium whereas rough endoplasmic reticulum decreases.
NIOSH-Publication; NIOSH-Grant; Liver-disorders; Metal-poisoning; Water-contamination; Morphology; Cytopathology; Food-contamination
Environmental Health Kettering Laboratory Eden & Bethesda Avenues Cincinnati, Ohio 45219
7440-50-8; 7440-66-6; 7440-43-9
Issue of Publication
American Journal of Anatomy
University of Cincinnati, Cincinnati, Ohio
Page last reviewed: September 2, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division