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The effect of sodium hydroxide and hydrochloric acid on human epidermis.
Nagao S; Stroud JS; Hamada T; Pinkus H; Birmingham DJ
Acta Derm Venereol 1972 Jan; 52(1):11-23
Electron microscopy of biopsy epidermis specimens obtained from the human forearm following the application of normal sodium-hydroxide (1310732) or normal hydrochloric-acid (7647010) reveals cellular and structural differences characteristic for each compound. Both treatments produce intracellular edema, the shortest time associated with recognizable changes in noncornified cells being 15 minutes with sodium-hydroxide and 120 minutes with hydrochloric-acid. The results establish a baseline for comparison with other concentrations of acid and base, and a variety of other agents, and can provide a better understanding of structural changes found in contact dermatitis.
NIOSH-Publication; NIOSH-Grant; Dermatitis; Electron-optics; Skin-disorders; Inorganic-acids; Allergic-reactions; Morphology; Cytopathology; Cytology; Histopathology; Alkalies
Dermatology Wayne State University 540 East Canfield Street Detroit, Mich 48201
Issue of Publication
Wayne State University, Detroit, Michigan
Page last reviewed: January 14, 2022
Content source: National Institute for Occupational Safety and Health Education and Information Division