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An electron microscopic study of human epidermis after acetone and kerosene administration.
Lupulescu AP; Birmingham DJ; Pinkus H
J Invest Dermatol 1973 Jan; 60(1):33-45
Electron microscopy reveals that exposure of human skin to acetone (67641) results in marked intracellular edema of keratinized cells and vacuolation of spinous cells, while kerosene induces large lacunae and disappearance of the keratin pattern in keratinized cells, and cytolysis of spinous cells. The cytoplasmic and nuclear degenerative changes are more pronounced after 90 minutes than following 30 minute exposure. A high degree of restoration of the normal ultrastructural pattern occurs at 72 hours after discontinuing exposure.
NIOSH-Publication; NIOSH-Grant; Dermatitis; Organic-solvents; Cytopathology; Subcellular-structure; Skin-disorders; Cytology; Electron-optics; Fuels; Histopathology; Dermatology; Ketones
Dermatology Wayne State University 540 East Canfield Street Detroit, Mich 48201
Issue of Publication
Journal of Investigative Dermatology
Wayne State University, Detroit, Michigan
Page last reviewed: November 20, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division