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Comparative changes in serum enzyme levels in beryllium- or carbontetrachloride-induced liver necrosis.
Proc Soc Exp Biol Med 1973 Sep; 143(4):1207-1210
The serum enzymes isocitric-dehydrogenase, lactic dehydrogenase, glutamic-pyruvic-transaminase, and glutamic-oxaloacetic- transaminase, and the liver enzyme acid phosphatase are used to evaluate the difference in the rat response to beryllium induced midzonal liver necrosis and carbon-tetrachloride induced centrilobular necrosis. Beryllium induced liver necrosis appears in many respects to be different from necrosis induced by carbon- tetrachloride, with a much longer time required for beryllium injected animals to exhibit a serum enzyme elevation.
Liver-disorders; Toxic-substances; Berylliosis; Enzyme-activity; Chlorinated-hydrocarbons; Light-metals; Metal-poisoning; Blood-chemistry; NIOSH-Author
7440-41-7; 56-23-5; 9001-58-5; 9001-60-9; 9013-64-3; 9000-86-6
Issue of Publication
Proceedings of the Society for Experimental Biology and Medicine
Page last reviewed: April 12, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division