Clinical manifestations of chromic-acid (7738945) toxicity are described for a group of electroplate workers, with particular emphasis being placed on the etiologic factors responsible for the development of nasal lesions. Skin and nasal structures of the workers are examined and recorded in terms of standard descriptive morphology, while environmental air samples are collected from various breathing zones. Demographic data are also collected for the population. Ninety five percent of employees exposed to low atmospheric concentrations of chromic-acid are shown to have nasal pathology, while a lesser number of employees appear to develop characteristic chrome induced skin lesions. A nasal pathology spectrum is demonstrated in which the development of increasingly severe lesions appears to be related to the worker's length of exposure to chromic acid. Hexavalent chromium (7440473) is implicated in the mechanism of nasal pathology.
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