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Chronic animal inhalation toxicity to cobalt.
Cincinnati, OH: U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 74-115, 1973 Oct; :1-37
The toxic effects of chronic exposure of swine by inhalation to 0.1 milligrams (present threshold limit value for workers) and 1.0 milligram of cobalt (7440484) metal powder per cubic meter of air for six hours at five days per week for three months are studied by pulmonary function tests, electrocardiograms, x-ray examinations, blood tests, skin tests, urinalysis, and electron microscopy and light microscopy examination of tissue. Observed phenomena include decrease in lung compliance and other pulmonary parameters, cardiovascular changes indicating functional abnormalities, and collagenization or increased amount of septal collagen in the lungs. The present threshold limit value for cobalt is judged to be inadequate for protection of workers.
NIOSH-Contract; NIOSH-Author; Contract-099-71-0019; Toxic-substances; Respiratory-system-disorders; Cardiovascular-system-disorders; Histopathology; Blood-chemistry; Heavy-metals; Air-contaminants; Hazardous-materials; Toxicology; Fibrosis
NTIS Accession No.
DHEW (NIOSH) Publication No. 74-115; TR-203-74; Contract-099-71-0019
National Institute for Occupational Safety and Health
Page last reviewed: April 12, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division