NIOSHTIC-2 Publications Search
Inhibition of histamine-induced airway constriction by ascorbic acid.
Zuskin-E; Lewis-AJ; Bouhuys-A
J Allergy Clin Immunol 1973 Apr; 51(4):218-226
The effect of ascorbic-acid (50817) on histamine induced airway constriction is studied in 17 human subjects, and on guinea-pig tracheal strips in-vitro. Ventilatory function was measured by recording partial expiratory flow volume (PEFV) curves on which maximum flow rates at 50% and 25% vital capacity are calculated following oral administration of 500 milligrams of ascorbic-acid, the mean reductions of ventilatory capacity being significantly smaller in comparison with placebo administration (P less than contractions induced by histamine and relaxes the tissue in the absence of other agents. Propranolol does not block the effect of ascorbic-acid in man (80 milligrams orally), but in-vitro relaxations of tracheal strips by ascorbic-acid are reduced by 2.5 micrograms of propranolol (525666). Ascorbic-acid probably has a direct effect on airway smooth muscle; in the guinea pig trachea, the effect may be mediated by beta-adrenergic receptors.
NIOSH-Publication; NIOSH-Grant; Pulmonary-system-disorders; Adrenergic-blocking-agents; Antihistamines; Airway-obstruction; Pulmonary-function-tests; Sensitizers; Pharmacology; Muscle-contractions; Therapeutic-agents; Aerosols; Bronchial-asthma
John B Pierce Fdn Lab John B Pierce Fdn Lab 290 Congress Avenue New Haven, Conn 06519
Issue of Publication
Journal of Allergy and Clinical Immunology
John B Pierce Fdn of Conn Inc, New Haven, Connecticut
Page last reviewed: April 12, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division