Airway dilatation and constriction in spontaneously breathing guinea pigs.
Douglas JS; Dennis MW; Ridgway P; Bouhuys A
J Pharmacol Exp Ther 1972 Jan; 180(1):98-189
Breath by breath recordings of tidal volume, air flow and pleural pressure, with on-line analog computation of dynamic lung compliance and pulmonary resistance, allow the quantitative assessment of actions of drugs on airways of guinea pigs under nearly physiological conditions. Isoproterenol reduces resistance but has little effect on compliance unless given to animals with induced airway constriction. Histamine usually reduces compliance more than it increases resistance and the compliance changes are dose-related. The experiments with inulin allow an estimate of the amounts of aerosolized drugs delivered to the airways. Aerosols appear to be a more efficient vehicle for the delivery of drugs to airways than solutions infused intravenously. Anesthesia reduces the guinea pig's sensitivity to histamine. Individual variations in the response to histamine among unanesthetized animals probably reflect differences in airway smooth muscle sensitivity to the drug.
NIOSH-Publication; NIOSH-Grant; Airway-obstruction; Pulmonary-function-tests; Physiological-responses; Sensitizers; Muscle-contractions; Statistical-analysis; Mechanical-properties; Plethysmographs; PM9005805
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