Airway constriction in guinea pigs: interaction of histamine and autonomic drugs.
Douglas-JS; Dennis-MW; Ridgway-P; Bouhuys-A
J Pharmacol Exp Ther 1973 Jan; 184(1):169-179
Dose-response curves to intravenous or aerosolized histamine were prepared in 131 guinea pigs using changes of dynamic lung compliance as a measure of response. The median effective dose values to aerosolized histamine varied according to a log normal distribution. Histamine responses were modified with various autonomic drugs. The results suggest that autonomic mediators interact with histamine in its effect on airway smooth muscle. The individual variability of histamine sensitivity may depend, in part, on the balance between cholinergic and beta adrenergic stimuli which impinge on airway smooth muscle.
NIOSH-Publication; NIOSH-Grant; Respiratory-mechanics; Physiological-responses; Statistical-analysis; Bronchoconstriction; Intracellular-alterations; Respiratory-functions; Nervous-system-functions; Respiratory-distress
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