Physiological approaches to detection of small airway disease.
Environ Res 1973 Sep; 6(3):253-264
Review of recent developments in the field of lung mechanics relating to the problem of obstructive airway disease and its detection. The importance of studying the behavior of the intrapulmonary airways during the compressed as well as the noncompressed state is stressed while discussing the role of premature airway closure, in contributing to the abnormalities of gas exchange associated with disease in the small peripheral airways. The possibility is explored that some alternative methods may be developed for detecting small airway disease other than frequency dependence of dynamic compliance, with some physiological approaches to studying the behavior of small peripheral airways in human subjects during life.
NIOSH-Author; Physiological-responses; Respiratory-functions; Lung-ventilation; Residual-volume; Perfusion; Pulmonary-function-tests; Measurement-methods; Airway-resistance
N. Leroy Lapp, Appalachian Laboratory for Occupational Respiratory Disease, National Institute of Occupational Safety and Health, U. S. Public Health Service, Morgantown, West Virginia 26505