Sensory irritation of the upper airways by airborne chemicals.
Toxicol Appl Pharmacol 1973 Feb; 24(2):279-297
Tests are conducted on 27 chemicals, all containing a double carbon group, to determine their potential sensory irritation properties to the upper respiratory tract when administered in aerosol form to mice. The essential molecular features for sensory irritant activity in these compounds are delineated. Correlation between the biological and chemical reactivity data suggests that these compounds initiate the sensory irritation reaction by associating with SH groups of a receptor molecule on the free nerve endings of the afferent trigeminal which are located at the surface of the nasal mucosa.
NIOSH-Publication; NIOSH-Grant; Pulmonary-system-disorders; Respiratory-irritants; Airborne-particles; Air-contamination; Sulfhydryls; Thiols; Sensory-perceptual-processes; Biochemistry
Occupational Health University of Pittsburgh 130 DE Soto Street Pittsburgh, PA 15213
Toxicology and Applied Pharmacology
University of Pittsburgh, Pittsburgh, Pennsylvania