Biochemical effects of 1,1-dichloroethylene in rats: dissociation of its hepatotoxicity from a lipoperoxidative mechanism.
Jaeger RJ; Trabulus MJ; Murphy SD
Toxicol Appl Pharmacol 1973 Mar; 24(3):457-467
The dose response and time course of hepatic injury following oral administration of 1,1-dichloroethylene (75354) are studied in rats by measuring hepatic glucose-6-phosphatase, serum alanine-alpha- ketoglutarate transaminase, hepatic-triglyceride, and pentobarbital sleeping time, and comparison to carbon-tetrachloride (56235) in terms of the ability to stimulate lipoperoxidation in-vitro and in- vivo. Results indicate that 1,1-dichloroethylene produces some of the same liver and serum enzyme changes associated with the hepatotoxicity of carbon-tetrachloride, but the mechanisms are dissimilar.
NIOSH-Publication; NIOSH-Grant; Grants-other; Toxicology; Pharmacology; Hepatotoxins; Metabolism; Liver-function; Biochemistry
Physiology Harvard University 665 Huntington Ave Boston, Mass 02115
Other Occupational Concerns; Grants-other
Toxicology and Applied Pharmacology
Harvard University, Boston, Massachusetts