Parathion and diisopropylfluorophosphate (DFP) toxicity in partially hepatectomized rats.
Jacobsen-PL; Spear-RC; Wei-E
Toxicol Appl Pharmacol 1973 Oct; 26(2):314-317
The toxic effects of parathion and diisopropylfluorophosphate (DFP) are found to increase or remain unchanged in rats after partial removal of the liver, with LD-50 values and blood cholinesterase activities used as indices of toxicity. The results are interpreted as suggesting that the toxicity of parathion is most likely not due to hepatic conversion to paraoxon.
NIOSH-Publication; NIOSH-Grant; Pharmacology; Toxicology; Organo-phosphorus-compounds; Insecticides; Liver-functions; Enzyme-activity; Cholinesterase-inhibitors; Detoxification; Blood-chemistry; Lethal-dose; Biotransformation; Biochemical-reactions
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Toxicology and Applied Pharmacology
University of California Berkeley, Berkeley, California