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Lead toxicity in mice with genetically different levels of d-aminolevulinic acid dehydratase.
Bull Environ Contam Toxicol 1973 Feb; 9(2):80-83
Lead is administered to three strains of mice with genetically different delta-aminolevulinic acid (ALA) dehydratase levels to elucidate the relationship of the enzyme to parameters of acute and subacute lead toxicity. Data are given for the lethal dose-50 of lead nitrate for the mice with different levels of ALA dehydratase activity, and for subacute lead toxicity in mice fed a 4% lead carbonate diet, using body weight, liver and kidney weight, hematocrit, and enzyme inhibition as indices. Results indicate that inhibition of ALA dehydratase activity is not related to acute or subacute lead toxicity as measured by physiological parameters.
NIOSH-Publication; NIOSH-Grant; Sulfhydryl-enzymes; Porphyrin-synthesis; Pharmacology; Toxic-substances; Bioassay; Lead-poisoning; Enzyme-activity; Acute-poisoning; Metal-poisoning
Public Health University of California 108 Earl Warren Hall Berkeley, Calif 94720
106-60-5; 7439-92-1; 598-63-0; 10099-74-8
Issue of Publication
Bulletin of Environmental Contamination and Toxicology
University of California Berkeley, Berkeley, California
Page last reviewed: May 5, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division