The effect of lung antibody on normal lung structure and function.
Burrell-R; Flaherty-DK; DeNee-PB; Abraham-JL; Gelderman-AH
Am Rev Respir Dis 1974 Jan; 109(1):106-113
The effect of passive immunization is studied in normal mice treated with homologously derived mouse lung antibody during a 9-week period. Pathologic changes result although the antisera are not acutely pneumotoxic. The antibody is found to localize in the focal areas on the alveolar septa as evidenced by immunofluorescence and to cause a monocytic infiltrate and necrosis of the lung as evidenced by increases in lactic dehydrogenase isoenzymes 2 and 3. After 4 weeks of treatment, the animals show distension of the airways distal to the terminal bronchioles, increased interstitial alveolar connective tissue, and an increased localization in the lung of bacteria that are cleared from the circulation. Similar changes might account for increased susceptibility to respiratory infection in persons with chronic respiratory disease.
NIOSH-Publication; NIOSH-Grant; Sensitization; Immunologic-tests; Immunopathology; Enzyme-activity; Respiratory-disorders; Immunologic-techniques; Lung-clearance; Respiratory-functions; Tissue-reactions; Toxicity; Bacterial-infection; Lung-disorders
Microbiology West Virginia University Med C Department of Microbiology Morgantown, W VA 26506
American Review of Respiratory Disease
West Virginia University, Morgantown, West Virginia