Lung antigen induced cell-mediated immune injury in chronic respiratory diseases.
Am Rev Respir Dis 1974 Jan; 109(1):114-123
Observations are presented of the role of cell-mediated immunity to lung antigens in the pathogenesis of chronic lung diseases with particular reference to the participation of delayed type autoaggressive hypersensitivity mechanisms. Normal guinea pigs are sensitized by injection of a soluble connective tissue extract (obtained by treating pig, rat, or human lung connective tissue with pH 3.2 citrate buffer) containing at least two potential antigenic fractions admixed in Freund's complete adjuvant. Results are presented of in vivo and in vitro assessments of delayed hypersensitivity to the connective tissue extract. A consistent increase in pathologic changes in the lungs at 8 and 16-week intervals is observed in animals sensitized with the connective tissue in Freund's complete adjuvant as compared with animals immunized with Freund's complete adjuvant alone. Delayed autoallergy to the extract is demonstrated in 3 experimental diseases (tuberculosis, berylliosis, and pneumoconiosis) in the guinea pig and rat, and suggestive evidence of similar participation of delayed autoallergy to antigens in the connective tissue extract is obtained in 3 of 9 human subjects with chronic respiratory disease. The results suggest that delayed hypersensitivity to endogenous lung antigens develops in response to pulmonary tissue damage and that cell-mediated immune injury might have a potentiating effect in certain chronic respiratory diseases.
NIOSH-Publication; NIOSH-Grant; Respiratory-disorders; Immunopathology; Immunopolysaccharides; Immunoproteins; Allergic-reactions; Pathogenicity; Skin-tests; Histopathology; Sensitization; Lung-lesions; Tissue-reactions
Microbiology West Virginia University Med C Department of Microbiology Morgantown, W VA 26506
American Review of Respiratory Disease
West Virginia University, Morgantown, West Virginia