Adaptation to the toxic effects of lead.
Am Ind Hyg Assoc J 1972 Nov; 33(11):756-760
In an experimental study, the susceptibility of male white albino mice to lead toxicity after pretreatment with a small intraperitoneal dose of lead nitrate was examined. Indices of lead toxicity chosen for study were lethality, body weight loss, liver and kidney weight changes, hematocrit, and inhibition of liver delta- aminolevulinic acid dehydratase activity. Pretreatment with lead nitrate (10 or 20 mg/kg intraperitoneal) protected mice against the acute lethal effects of a 200-mg/kg intraperitoneal dose of lead nitrate, the optimal time of pretreatment being 4 days before the challenge dose. Pretreatment with lead nitrate (20 mg/kg intraperitoneal) did not attenuate and may have exacerbated the subacute lead toxicity induced by a 4% basic lead carbonate diet fed over a 12-day period. It appears that only selected biological parameters develop resistance to lead.
NIOSH-Publication; NIOSH-Grant; Levulinic-acids; Adaptation
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American Industrial Hygiene Association Journal
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