Serum trypsin inhibitor capacity and purulent sputum.
Am Rev Respir Dis 1972 Oct; 106(5):772-773
Abnormal serum activities of alpha(1)-antitrypsin have been found in association with a variety of pathologic conditions. It has also been shown that the proteinase inhibitor is genetically determined, and 3 values of trypsin inhibitor capacity (TIC: milligrams of trypsin (9002077) inhibited per milliliter of serum) have been recognized. The purpose of this study was to determine whether the presence of a purulent sputum had any significant effect on alpha(1)- antitrypsin values. In 16 patients, the products of purulent sputum, without overt signs of more severe infection, were associated with an increase in serum trypsin inhibitor capacity.
Serology; Pathology; Enzymatic-inhibition; Genetics; Screening; Respiratory-system-disorders; Excretions; Epidemiology; NIOSH-Author
American Review of Respiratory Disease