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Responses of alveolar macrophages to metals I. Inhalation of lead and nickel.
Bingham E; Barkley W; Zerwas M; Stemmer K; Taylor P
Arch Environ Health 1972 Dec; 25(6):406-414
Histopathological examination of lungs by light microscopy, and measurement of the number of alveolar microphages available by a standard washing procedure, for animals subjected to inhalation of soluble and insoluble aerosols of lead or nickel, Pb-C12, Pb2-03, Ni- C12, and NiO, near or below the levels proposed as acceptable for occupational exposures. The number of available macrophages increased for NiO, decreased for Pb2-03, and was not changed for Pb- Cl2, and Ni-Cl1. However, distribution in cell sizes varied with exposure. Observed histopathological changes from nickel compounds are cited as requiring a lowering of the threshold limit value for nickel and nickel compounds.
NIOSH-Publication; NIOSH-Grant; Respiratory-system-disorders; Metal-poisoning; Air-contaminants; Airborne-particles; TLV; Physiological-effects; Cytology; Toxicology
Environmental Health University of Cincinnati College of Medicine Cincinnati, Ohio 45219
7439-92-1; 7440-02-0; 7758-95-4; 1314-37-8; 7718-54-9; 1313-99-1
Issue of Publication
Archives of Environmental Health
University of Cincinnati, Cincinnati, Ohio
Page last reviewed: November 13, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division