Respiratory uptake of ozone in dogs.
Arch Environ Health 1972 Aug; 25(2):132-138
Measurement of the uptake of ozone by the surgically isolated upper airways in 11 anesthetized, paralyzed, mechanically ventilated dogs. The gas was administered either by nose or mouth, each exposure lasting 20 to 30 minutes. The relative uptake of ozone was found to be inversely related to concentration and flow rate, and was higher nasally than orally. Changes in nasal flow resistance, induced by aerosols of histamine and phenylephrine hydrochloride, had little effect on the process. The removal of ozone from inspired air by the lower airways and parenchyma was measured in five additional dogs that were mechanically ventilated through a tracheal cannula. The concentration ranged from 0.20 parts per million (ppm) to 0.85 ppm; the tidal volume was constant, and the pump frequently was either 20 or 30 cycles per minute. Under these circumstances, the rate of uptake varied between 80 percent and 87 percent.
NIOSH-Publication; NIOSH-Grant; Respiration; Respiratory-functions; Gases; Breathing; Inspiration
Preventive Medicine University of Washington Dept of Preventive Medicine Seattle, Wash 98105
10028-15-6; 61-76-7; 51-45-6
Archives of Environmental Health
University of Washington, Seattle, Washington