Irradiation-induced lesions in germfree rats.
J Natl Cancer Inst 1971 Jul; 47(1):229-234
Radiological study of irradiation induced lesions in germ free rats. Germfree Wistar and Fischer rats were subjected to whole body sublethal doses of X-rays and many developed malignant and benign neoplastic and degenerative lesions within 15 minutes. Untreated, germ free, control rats of the same age were disease free. Control, untreated, conventional Wistar rats, at age 15 months, had developed an extensive array and high incidence of malignant and benign neoplasms, degenerative lesions, and lung infections. The source and nature of pathogens in the environment of conventional rats were not determined. A life shortening effect of X-irradiation was not demonstrated, because rats were killed for examinations.
NIOSH-Publication; NIOSH-Grant; Radiology; Ionizing-radiation; Cancer; Respiratory-disorders; Carcinogenesis
Lobund Laboratory University of Notre Dame Lobound Laboratory Notre Dame, Ind 46556
Journal of the National Cancer Institute
University of Notre Dame, Notre Dame, Indiana