Reduction of ketones in liver cytosol.
Xenobiotica 1971 Jan; 1(1):97-104
Determination of location and some characteristics of enzymatic reduction of ketones in liver homogenates of rats and rabbits, incubated with ketones (acetone, 2-butanone, acetophenone, benzophenone, deoxybenzoin, metyrapone) or alcohols (isopropanol, 2- butanol, 1-phenylethonol, benzhydrol, 1,2-diphenylethanol, metyropol). The predominant site for the hepatic reduction of aromatic and aliphatic ketones is the cytosol. Acetophenone reductase activity is not enhanced in liver cystol after treatment of rats with phenobarbital. Ketone reductase activity was found in the cytosol fractions of some non-hepatic tissues, particularly that of the kidney.
NIOSH-Publication; NIOSH-Grant; Metabolism; Liver-functions; Kidney-functions; Enzyme-activity
Pharmacology and Therapeutics Univ of Florida Coll of Med Dept of Pharma & Therapeutics Gainesville, Fla 32601
67-64-1; 78-93-3; 98-86-2; 78-92-2; 91-01-0; 119-61-9; 67-63-0; 54-36-4; 98-85-5
University of Florida Gainesville, Gainesville, Florida