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Observations concerning alveolar dust clearance.
Department of Radiation Biology and Biophysics, School of Medicine and Dentistry (Unpublished; Presented at the International Conference on Coal Workers' Pneumoconiosis, New York, September 13-17, 1971), Rochester, New York, 1971 Sep; :1-18
Experiments with rats exposed to titanium-dioxide (7440326) dust reveal that the onset of alveolar clearance is immediate in terms of minutes, overlapping in time with the rapid clearance of particles from the tracheobronchial tree. Two days after the onset of exposure the number of alveolar macrophages is significantly increased. In 88 days (half time), 50 percent of the initial lung burden is cleared. Multiple exposures may change the clearance rate. Clearance efficiency may improve by experimental means. Lung clearance of titanium-dioxide in animals subjected to preliminary exposure to sulfur-dioxide (7446095) is significantly depressed.
NIOSH-Grant; Respiratory-functions; Lung-clearance; Respiratory-mechanics; Inorganic-gases; Toxic-gases; Dust-inhalation; Lung-dust-burden
Radiation Biology & Biophysics University of Rochester Dept of Radiation Bio & Biophy Rochester, N Y 14620
Department of Radiation Biology and Biophysics, School of Medicine and Dentistry (Unpublished; Presented at the International Conference on Coal Workers' Pneumoconiosis, New York, September 13-17, 1971), Rochester, New York, 18 pages, 26 references
University of Rochester, Rochester, New York
Page last reviewed: January 14, 2022
Content source: National Institute for Occupational Safety and Health Education and Information Division