Preventing Asthma in Animal Handlers


January 1998
DHHS (NIOSH) Publication Number 97-116
cover of NIOSH Alert 97-116


The principal contributors to this Alert were Gina Buono, Bradley Husberg, Hector Ortega, Edward Petsonk, Dorothy Tan-Wilhelm, and John Parker. Please direct comments, questions, or requests for additional information to the following:

Division of Respiratory Disease Studies
1095 Willowdale Road
Morgantown, WV 26505-2888

Telephone, (304) 285-5750; or call 1-800-35-NIOSH (1-800-356-4674).

We greatly appreciate your assistance in protecting the lives of U.S. workers.

Linda Rosenstock, M.D., M.P.H.
Director, National Institute for Occupational Safety and Health
Centers for Disease Control and Prevention


Aoyama K, Ueda A, Manda F, Matsushita T, Ueda T, Yamauchi C [1992]. Allergy to laboratory animals: an epidemiological study. Br J Ind Med 49(1):41-47.

Bardana EJ Jr. [1992]. Occupational asthma and related conditions in animal workers. In: Bardana EJ Jr., Montanaro A, O’Hollaren MT, eds. Occupational asthma. Philadelphia, PA: Hanley & Belfus.

Bar-Sela S, Teichtahl H, Lutsky I [1984]. Occupational asthma in poultry workers. J Allergy Clin Immunol 73(2):271-275.

Beckett WS [1994]. The epidemiology of occupational asthma. Eur Respir J 7:161-164.

Brooks SM [1992]. Occupational and environmental asthma. In: Rom WN, ed. Environmental and occupational medicine. 2nd ed. Boston, MA: Little, Brown and Company, pp. 393-446.

Bryant DH, Boscato LM, Mboloi PN, Stuart MC [1995]. Allergy to laboratory animals among animal handlers. Med J Aust 163(8):415-418.

Chan-Yeung M, Malo JL [1994]. Aetiological agents in occupational asthma. Eur Respir J 7:346 -371.

DeGroot AC, Messerschmidt HJM [1984]. Laboratory animal allergy. Contact Dermatitis 11(2):121-122.

Edwards RG, Beeson MF, Dewdney JM [1983]. Laboratory animal allergy: the measurement of airborne urinary allergens and the effects of different environmental conditions. Lab Anim 17(3):235-239.

Eggleston PA, Wood RA [1992]. Management of allergies to animals. Allergy Proc 13(6):289-292.

Gordon S, Tee RD, Lowson D, Wallace J, Newman Taylor AJ [1992]. Reduction of airborne allergenic urinary proteins from laboratory rats. Br J Ind Med 49(6):416-422.

Harries MG, Cromwell O [1982]. Occupational asthma caused by allergy to pigs’ urine. Br Med J Clin Res 284(6319):867.

Hollander A, Heederik D, Doekes G [1997]. Respiratory allergy to rats: exposure-response relationships in laboratory animal workers. Am J Respir Crit Care Med 155:562-567.

Hunskaar S, Fosse RT [1993]. Allergy to laboratory mice and rats: a review of its prevention, management, and treatment. Lab Anim 27(3):206-221.

Kibby T, Powell G, Cromer J [1989]. Allergy to laboratory animals: a prospective and cross-sectional study. J Occup Med 31(10):842-846.

Lincoln TA, Bolton NE, Garrett AS Jr. [1974]. Occupational allergy to animal dander and sera. J Occup Med 16(7):456-469.

Lutsky I, Baum GL, Teichtahl H, Mazar A, Aizer F, Bar-Sela S [1985]. Occupational respiratory disease in veterinarians. Ann Allergy 55:153-156.

Newill CA, Evans III R, Khoury MJ [1986]. Preemployment screening for allergy to laboratory animals: epidemiologic evaluation of its potential usefulness. J Occup Med 28(11):1158-1164.

Newman-Taylor AJ, Gordon S [1993]. Laboratory animal and insect allergy. In: Bernstein IL, Chan-Yeung M, Malo J-L, Bernstein DI, eds. Asthma in the workplace. New York, NY: Marcel Dekker, Inc., pp. 399-414.

NHLBI (National Heart, Lung, and Blood Institute) [1995]. Global initiative for asthma. Global strategy for asthma management and prevention. NHLBI/WHO Workshop Report. Bethesda, MD: U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, NIH Publication No. 95-3659.

Ohman JL Jr. [1978]. Allergy in man caused by exposure to mammals. J Am Vet Med Assoc 172(1):1403-1406.

Paggiaro PL, Vagaggini B, Bacci E, Bancalari L, Carrara M, Di Franco A, et al. [1994]. Prognosis of occupational asthma. Eur Respir J 7:761-767.

Parker JE, Petsonk EL, Weber SL [1992]. Hypersensitivity pneumonitis and organic dust toxic syndrome. Immunol and Allergy Clin of North America 12(2):279-290.

Renström A, Maimberg P, Larsson K, Sundblad B-M [1995]. Allergic sensitization is associated with increased bronchial responsiveness: a prospective study of allergy to laboratory animals. Eur Respir J 8:1514-1519.

Sakaguchi M, Inouye S, Miyazawa H, Kamimura H, Kimura M, Yamazaki S [1990]. Evaluation of countermeasures for reduction of mouse airborne allergens. Lab Anim Sci 40(6):613-615.

Salvaggio JE, Taylor G, Weill H [1986]. Occupational asthma and rhinitis. In: Merchant JA, ed. Occupational respiratory diseases. Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 86-102, pp. 461-477.

Venables KM, Chan-Yeung M [1997]. Occupational asthma. Lancet 349:1465-1469.

Venables KM, Farrer N, Sharp L, Graneek BJ, Newman-Taylor AJ [1993]. Respiratory symptoms questionnaire for asthma epidemiology: validity and reproducibility. Thorax 48(3):214-219.

Watt AD, McSharry CP [1996]. Laboratory animal allergy: anaphylaxis from a needle injury. Occup Environ Med 53:573-574.

Zejda JE, Hurst TS, Rhodes CS, Barber EM, McDuffie HH, Dosman JA [1993]. Respiratory health of swine producers. Focus on young workers. Chest 103(3):702-709.

Zuskin E, Kanceljak B, Stilinovic L, Schachter EN, Kopjar B [1992a]. Immunological status and respiratory findings in furriers. Am J Ind Med 21(3):433-441.

Zuskin E, Zagar Z, Schachter EN, Mustajbegovic J, Kern J [1992b]. Respiratory symptoms and ventilatory capacity in swine confinement workers. Br J Ind Med 49(6):435-440.

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