Immediately Dangerous to Life or Health (IDLH) Value Profile: Ethylene Dibromide (CAS® No. 106-93-4)
DHHS (NIOSH) Publication Number 2020-125
Overview of the IDLH Value for Ethylene Dibromide
IDLH Value: 46 ppm (354 mg/m3)
Basis for IDLH Value: The immediately dangerous to life or health (IDLH) value for ethylene dibromide is based on a 36-minute no observed adverse effect level (NOAEL) for lethality value of 400 ppm in rats [Rowe et al. 1952]. The duration-adjusted value for a 30-minute exposure is 456 ppm. An uncertainty factor (UF) of 10 was applied (1 to account for interspecies variability [animal to human] and 10 to account for human variability). This resulted in a point of departure (POD) of 456 ppm, divided by a UF of 10 or an IDLH of 46 ppm.
This IDLH Value Profile presents a brief summary of technical data associated with acute inhalation exposures to ethylene dibromide and the rationale behind the IDLH value for ethylene dibromide. IDLH values are developed on the basis of scientific rationale and logic outlined in the NIOSH Current Intelligence Bulletin (CIB) 66: Derivation of Immediately Dangerous to Life or Health (IDLH) Values [NIOSH 2013].
NIOSH . Immediately dangerous to life or health (IDLH) value profile: ethylene dibromide, CAS® No. 106-93-4. By Niemeier RT. Cincinnati, OH: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 2020-125, https://doi.org/10.26616/NIOSHPUB2020125