Immediately Dangerous to Life or Health (IDLH) Value Profile, Diketene [CAS® No. 674-82-8]
DHHS (NIOSH) Publication Number 2017-108 [CAS® No. 674-82-8]
Basis for IDLH value: The IDLH value for diketene is based on the rat BMCL05 of 181 ppm for lethality in a 1-hour exposure [Katz 1987]. The duration adjusted BMCL05 for a 30-minute exposure is 228 ppm. A composite uncertainty factor of 30 was applied to account for extrapolation from a lethal concentration threshold in animals, animal to human differences, human variability, and database uncertainties, resulting in an IDLH value of 7.6 ppm.
NIOSH . Immediately dangerous to life or health (IDLH) Value Profile: diketene. By Dotson GS, Maier A, Parker A, Haber L. Cincinnati, OH: US Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication 2017-108.