Immediately Dangerous to Life or Health (IDLH) Value Profile, Diketene [CAS® No. 674-82-8]
DHHS (NIOSH) Publication Number 2017-108 [CAS® No. 674-82-8]
Basis for IDLH value: The IDLH value for diketene is based on the rat BMCL05 of 181 ppm for lethality in a 1-hour exposure [Katz 1987]. The duration adjusted BMCL05 for a 30-minute exposure is 228 ppm. A composite uncertainty factor of 30 was applied to account for extrapolation from a lethal concentration threshold in animals, animal to human differences, human variability, and database uncertainties, resulting in an IDLH value of 7.6 ppm.
Immediately Dangerous to Life or Health (IDLH) Value Profile, Diketenepdf icon [CAS® No. 674-82-8] [PDF – 329 KB]
NIOSH . Immediately dangerous to life or health (IDLH) Value Profile: diketene. By Dotson GS, Maier A, Parker A, Haber L. Cincinnati, OH: US Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication 2017-108.