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Immediately Dangerous to Life or Health (IDLH) Value Profile, Diketene [CAS® No. 674-82-8]

December 2016
DHHS (NIOSH) Publication Number 2017-108 [CAS® No. 674-82-8]
Cover shot of Immediately Dangerous to Life or Health Value Profile for Diketene

Basis for IDLH value: The IDLH value for diketene is based on the rat BMCL05 of 181 ppm for lethality in a 1-hour exposure [Katz 1987]. The duration adjusted BMCL05 for a 30-minute exposure is 228 ppm. A composite uncertainty factor of 30 was applied to account for extrapolation from a lethal concentration threshold in animals, animal to human differences, human variability, and database uncertainties, resulting in an IDLH value of 7.6 ppm.

Suggested Citation

NIOSH [2016]. Immediately dangerous to life or health (IDLH) Value Profile: diketene. By Dotson GS, Maier A, Parker A, Haber L. Cincinnati, OH: US Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication 2017-108.

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