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Request for comments on NIOSH draft method 8324 (3-Bromopropionic acid in urine; A metabolite of 1-bromopropane)

April 2014
NIOSH Docket Number 273, CDC-2014-0006

The National Institute for Occupational Safety and Health (NIOSH) of the Centers for Disease Control and Prevention (CDC) intends to publish a new method in the NIOSH Manual of Analytical Methods (NMAM). This method is entitled "Method 8324: 3-Bromopropionic acid in urine; A metabolite of 1-bromopropane."

1-Bromopropane is an industrial solvent often used as a substitute for a number of chlorofluorocarbon solvents which have been withdrawn from use because of their possible damaging effects to the ozone layer. 3-Bromopropionic acid is a human metabolite of 1-bromopropane and a proposed biomarker of exposure. An accurate and precise method was developed for the detection and quantitation of 3-bromopropionic acid in human urine. This method has been published in the literature (B'Hymer CB, Cheever KL [2004]. J Chromatogr B 802:361-366). The method has been further validated by a second laboratory and is proposed for inclusion in NMAM's 5th Edition.

To view the notice and related materials, visit and enter CDC-2014-0006 in the search field and click "Search."

Public Comment Period

Comments will be accepted until 5:00 p.m. EST on June 10, 2014.

Written comments, identified by CDC-2014-0006 and docket number NIOSH-273, may be submitted by any of the following methods:

  • Federal rulemaking portal: Follow the instructions for submitting comments.

    Instructions: All submissions received must include the agency name and docket number. All relevant comments, including any personal information provided, will be posted without change to

  • Mail: NIOSH Docket Office
    Robert A. Taft Laboratories
    4676 Columbia Parkway
    Cincinnati, OH 45226