Manufacturing

Burden

Approximately 82,000 chemicals are currently used in industry with an estimated 700 new chemicals being introduced annually resulting in a high potential for occupational exposure [GAO 2005]. Occupational exposures to chemicals can result in numerous diseases which can adversely affect an individual’s health and capacity to perform at work with associated costs estimated to exceed $1 billion annually in the United States alone [Cashman et al. 2012, Mancini et al. 2008]. The two most common routes of occupational exposure to chemicals is through the skin and lungs.  Hundreds of chemicals present in virtually every industry (metals, epoxy and acrylic resins, rubber additives, chemical intermediates) have been identified to cause immune mediated disorders such as contact dermatitis and asthma or other systemic effects [Anderson and Meade 2014]. The manufacturing sector includes a number of professions such as printing, petroleum and coal products manufacturing, chemical manufacturing, automotive manufacturing, plastic and rubber products manufacturing, metal manufacturing and furniture manufacturing in which a high potential for exposure to toxic chemicals exists. Contact dermatitis is the second most commonly reported occupational illness accounting for 10% to 15% of all occupational diseases and the Manufacturing sector has the highest number of cases (26,000) and the second highest reported incidence (139 per 100,000) of occupational skin diseases among major industries [Lushniak 2003]. Additionally, there are over 80 chemicals used in the manufacturing sector including amines, acrylates, aid anhydrides, and isocyanates that are associated with occupational asthma. Isocyanates (chemicals used in many products, including polyurethane foams and automotive paint) are considered to be some of the most common occupational asthmogens.

Need

Chemicals are used very commonly in workplaces for purposes such as disinfection and in manufacturing and production.  However, there is also a responsibility to provide a safe and healthy environment for workers. While immunological mechanism are suggested for occupational disorders due to chemical exposures, research in this area is still lacking.  Overall, there is a need to better understand the adverse impact of chemicals on occupational immune health.

To minimize the hazards of dermal and respiratory occupational exposures and immune diseases, research is needed to understand the mechanisms driving the diseases related to exposure. Exposure monitoring to identify, evaluate and prevent occupational chemical exposure is important. This can help to determine the type and route of exposure, the effectiveness of engineering controls, how to improve work practices, appropriate personal protective equipment, and provide risk assessment guidance to regulators. Workers should be aware not only of the hazards associated with the chemicals in their environment but also the best ways to protect them from exposure and disease. Research involving matching the personal protective technology/equipment (PPE) appropriate to the hazard is needed in these industries. Different glove materials differ in their ability to prevent dermal hazards and research is needed in this area regarding the protective factors of gloves and their ability to protect manufacturing workers from dermal exposures.