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Registry of Toxic Effects of Chemical Substances (RTECS)

Zinc, bis(dimethyldithiocarbamato)-

RTECS #

ZH0525000

CAS #

137-30-4; 8059-74-3; 8070-07-3; 12768-61-5; 12773-04-5; 14459-91-7; 17125-91-6; 31300-71-7; 55870-88-7; 98391-07-2; 111922-61-3

Updated

June 2017

Molecular Weight

305.81

Molecular Formula

C6H12N2S4·Zn

Synonyms

Aaprotect
Aavolex
Aazira
Accelerator L
Aceto ZDED
Alcobam ZM
Bis(dimethylcarbamodithioato-S,S')zinc
Bis(dimethyldithiocarbamato)zinc
Bis(N,N-dimetil-ditiocarbammato) di zinco (Italian)
Bis-dimethyldithiocarbamate de zinc (French)
Carbamic acid, dimethyldithio-, zinc salt (2:1)
Carbazinc
Corona corozate
Corozate
Cuman
Cuman L
Cymate
Dimethylcarbamodithioic acid, zinc complex
Dimethylcarbamodithioic acid, zinc salt
Dimethyldithiocarbamate zinc salt
Dimethyldithiocarbamic acid, zinc salt
Drupina 90
ENT 988
Eptac 1
Fuclasin
Fuclasin Ultra
Fuklasin
Fungostop
Hermat ZDM
Hexazir
Karbam White
Methasan
Methazate
Methyl zimate
Methyl zineb
Methyl Ziram
Mezene
Milbam
Molurame
Mycronil
NCI-C50442
Orchard brand ziram
Pomarsol Z forte
Prodaram
Rhodiacid
Soxinal PZ
Soxinol PZ
Tricarbamix Z
Triscabol
Tsimat
Tsiram (Russian)
USAF P-2
Vancide MZ-96
Vulcacure ZM
Vulkacit L
Vulkacite L
Z 75
Zarlate
Z-C spray
ZDMC
Zerlate
Zimate
Zinc bis(dimethyldithiocarbamate)
Zinc bis(dimethyldithiocarbamoyl)disulphide
Zinc bis(dimethylthiocarbamoyl)disulfide
Zinc dimethyldithiocarbamate
Zinc N,N-dimethyldithiocarbamate
Zink-(N,N-dimethyl-dithiocarbamat) (German)
Zink-bis(N,N-dimethyl-dithiocarbamaat) (Dutch)
Zink-bis(N,N-dimethyl-dithiocarbamat) (German)
Ziradin
Ziram
Ziram technical
Ziramvis
Zirasan
Zirasan 90
Zirberk
Zirex 90
Ziride
Zirthane
Zitox

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislymphocyte/human10 nmol/LTXCYAC 4,331,1975
Cytogenetic Analysisoral/mouse1750 mg/kg/5D-continuousMUREAV 208,57,1988
Cytogenetic Analysisovary/hamster25 µg/LSCIEAS 236,933,1987
DNA Damageintraperitoneal/rat50 mg/kgMUREAV 302,1,1993
DNA Damage/Escherichia coli1 µmol/LARTODN 46,277,1980
DNA inhibitionother cell types/rat100 µg/LARTODN 45,101,1980
DNA inhibitionlymphocyte/human1 mg/LARTODN 45,101,1980
DNA repair/Bacillus subtilis600 ng/discMUREAV 40,19,1976
micronucleus testunreported route/mouse350 mg/kg/24HMUREAV 208,57,1988
micronucleus testlymphocyte/human10 mg/L/21H (-enzymatic activation step)MUREAV 497,89,2001
morphological transformfibroblast/mouse1 µg/L/21D (-enzymatic activation step)EMMUEG 37,231,2001
mutation in mammalian somatic cellslymphocyte/mouse62500 ng/LEMMUEG 12,85,1988
mutation in microorganisms/Salmonella typhimurium10 mg/L/2H (+enzymatic activation step)EMMUEG 44,329,2004
mutation in microorganisms/Salmonella typhimurium5 µg/plate (+/-enzymatic activation step)MUREAV 68,313,1979
sex chromosome loss and nondisjunctionoral/Drosophila melanogaster500 mg/LSWEHDO 9(Suppl 2),27,1983
sister chromatid exchangeovary/hamster25 µg/LEMMUEG 13,133,1989
specific locus testoral/Drosophila melanogaster130 ppmMUREAV 224,161,1989

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 500 mg/kg (6-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
EESADV 7,531,1983
oral/rat 250 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)EESADV 7,531,1983
oral/rat 1 gm/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) systemEESADV 7,531,1983
oral/rat 500 mg/kg (6-15D pregnant)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)EESADV 7,531,1983

Tumorigenic Data and References

Route/OrganismDoseEffectReference
implant/rat lowest published toxic dose: 60 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Skin and Appendages: Tumors
VPITAR 29,71,1970
oral/mouse lowest published toxic dose: 840 mg/kg/13W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
GISAAA 37(9),25,1972
oral/mouse lowest published toxic dose: 87962 mg/kg/103W- intermittentTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
NTIS** PB83-202622
oral/mouse lowest published toxic dose: 178808 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
NTIS** PB83-202622
oral/rat lowest published toxic dose: 12978 mg/kg/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Endocrine: Thyroid tumors

Skin and Appendages: Tumors
NTPTR* NTP-TR-238,1982
oral/rat toxic dose: 25956 mg/kg/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Endocrine: Thyroid tumors

Skin and Appendages: Tumors
NTPTR* NTP-TR-238,1982
oral/rat toxic dose: 13160 mg/kg/94W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Skin and Appendages: Tumors
VPITAR 29,71,1970
oral/rat lowest published toxic dose: 7931 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Endocrine: Thyroid tumors
NTIS** PB83-202622

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Rat, neurons Inhibitor Concentration Low: 40 µmol/L/1HIn Vitro Toxicity Studies: Cell Viability (cell death), unspecified assayNRTXDN 44,204,2014
In Vitro/Rat, neurons Inhibitor Concentration Low: 40 µmol/L/1HIn Vitro Toxicity Studies: Other assaysNRTXDN 44,204,2014
inhalation/mouse lethal concentration (50 percent kill): >1056 mg/m3/2HEye: Corneal damage

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea
GTPZAB 12(4),12,1968
inhalation/rat lethal concentration (50 percent kill): 26 mg/m3/2HNTIS** OTS0540394
intraperitoneal/guinea pig lowest published lethal dose: 30 mg/kgBehavioral: ComaJAPMA8 41,662,1952
intraperitoneal/mouse lethal dose (50 percent kill): 15500 µg/kgNNGADV 17,S155,1992
intraperitoneal/rabbit lowest published lethal dose: 50 mg/kgBehavioral: ComaJAPMA8 41,662,1952
intraperitoneal/rat lethal dose (50 percent kill): 8700 µg/kgNNGADV 17,S155,1992
intravenous/mouse lethal dose (50 percent kill): 18 mg/kgCSLNX* NX#04886
oral/guinea pig lethal dose (50 percent kill): 200 mg/kgFATOAO 32,356,1969
oral/mouse lethal dose (50 percent kill): 480 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)
FATOAO 28,230,1965
oral/rabbit lethal dose (50 percent kill): 400 mg/kgPCOC** -,1250,1966
oral/rat lethal dose (50 percent kill): 267 mg/kgEPASR* 8EHQ-1090-1045
oral/wild bird lethal dose (50 percent kill): 100 mg/kgTXAPA9 21,315,1972
skin/rabbit lethal dose (50 percent kill): >2 gm/kgEPASR* 8EHQ-1090-1045
skin/rat lethal dose (50 percent kill): >6 gm/kgFMCHA2 -,C329,1991
subcutaneous/mouse lethal dose (50 percent kill): 309 mg/kgNNGADV 17,S155,1992
subcutaneous/rat lethal dose (50 percent kill): 69 mg/kgNNGADV 17,S155,1992
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 1400 mg/kg30ZDA9 -,213,1971
unreported route/rat lethal dose (50 percent kill): 1230 mg/kgEQSSDX 3,618,1975

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 5 mg/m3/4H/17W- intermittentBlood: Normocytic anemia

Blood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count
GTPZAB 12(4),12,1968
oral/Dog lowest published toxic dose: 9125 mg/kg/1Y- continuousBehavioral: Convulsions or effect on seizure threshold

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JPETAB 118,174,1956
oral/Dog lowest published toxic dose: 28 mg/kg/4W- continuousGastrointestinal: Hypermotility, diarrheaNNGADV 17,S155,1992
oral/Dog lowest published toxic dose: 3640 mg/kg/2Y- continuousGastrointestinal: Hypermotility, diarrhea

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
NNGADV 17,S155,1992
oral/mouse lowest published toxic dose: 16800 mg/kg/14D- continuousGastrointestinal: Hypermotility, diarrhea

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-238,1983
oral/mouse lowest published toxic dose: 27300 mg/kg/13W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-238,1983
oral/mouse lowest published toxic dose: 141316 mg/kg/103W- intermittentLiver: Tumors

Tumorigenic: Active as anti-cancer agent
NTIS** PB83-202622
oral/rat lowest published toxic dose: 436.8 gm/kg/104W- continuousPeripheral Nerve and Sensation: Structural change in nerve or sheath

Musculoskeletal: Other changes
TXCYAC 54,45,1989
oral/rat lowest published toxic dose: 18746 mg/kg/103W- intermittentSkin and Appendages: Tumors

Tumorigenic: Active as anti-cancer agent
NTIS** PB83-202622
oral/rat lowest published toxic dose: 22750 mg/kg/13W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-238,1983
oral/rat lowest published toxic dose: 80080 mg/kg/2Y- continuousBehavioral: Food intake (animal)

Endocrine: Changes in spleen weight

Endocrine: Changes in thyroid weight
NNGADV 17,S155,1992
oral/rat lowest published toxic dose: 45 gm/kg/30D- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainJAPMA8 41,662,1952
oral/rat lowest published toxic dose: 770 mg/kg/4W- continuousLiver: Changes in liver weight

Endocrine: Changes in spleen weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
NNGADV 17,S155,1992
oral/rat lowest published toxic dose: 4368 mg/kg/104W- continuousNutritional and Gross Metabolic: Changes in: CaTXCYAC 54,45,1989
oral/rat lowest published toxic dose: 10.9 gm/kg/26W- continuousBlood: Changes in erythrocyte (RBC) countTXCYAC 54,45,1989
oral/rat lowest published toxic dose: 54.6 gm/kg/13W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainTXCYAC 54,45,1989
oral/rat lowest published toxic dose: 327.6 gm/kg/78W- continuousMusculoskeletal: Other changesTXCYAC 54,45,1989
oral/rat lowest published toxic dose: 436.8 gm/kg/104W- continuousPeripheral Nerve and Sensation: Structural change in nerve or sheathTXCYAC 54,45,1989
oral/rat lowest published toxic dose: 2184 mg/kg/52W- continuousBlood: Changes in erythrocyte (RBC) countTXCYAC 54,45,1989
oral/rat lowest published toxic dose: 109.2 gm/kg/26W- continuousNutritional and Gross Metabolic: Changes in: CaTXCYAC 54,45,1989
oral/rat lowest published toxic dose: 218.4 gm/kg/52W- continuousEndocrine: Changes in thyroid weightTXCYAC 54,45,1989

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 53,423,1991
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 12,259,1976
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 12,259,1976
International Agency for Research on Cancer (IARC)Cancer Review:Human No Available DataIMEMDT 53,423,1991
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 53,423,1991
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWENTOX* -,86,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWJTEHD6 7,1,2004
TOXICOLOGY REVIEWFEREAC 71,24615,2006
TOXICOLOGY REVIEWFEREAC 73,31788,2008
TOXICOLOGY REVIEWHUTOX* -,561,1996
TOXICOLOGY REVIEWFEREAC 73,54954,2008
TOXICOLOGY REVIEWTXCYAC 307,24,2013
TOXICOLOGY REVIEWTXCYAC 307,123,2013
TOXICOLOGY REVIEWTXAPA9 268,157,2013
TOXICOLOGY REVIEWMUREAV 802,1,2016

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,174,1998
Occupational Exposure Limit-GERMANYMAK 0.1 mg(Zn)/m3, inhal, 2011
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.3 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 1 mg/m3;short term exposure limit 2 mg/m3 (total. dust), Sen, JUN2005
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 1 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 80305; Number of Industries 20; Total Number of Facilities 2044; Number of Occupations 23; Total Number of Employees Exposed 34594; Total Number of Female Employees Exposed 5542
National Occupational Hazard Survey 1974Hazard Code 80305; Number of Industries 5; Total Number of Facilities 267; Number of Occupations 27; Total Number of Employees Exposed 3838

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0493-8821;8EHQ-0892-8916
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8918
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (feed);clear evidence:rat
NCI Carcinogenesis Studies (feed);equivocal evidence:mouse
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