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Registry of Toxic Effects of Chemical Substances (RTECS)

Zinc, (ethylenebis(dithiocarbamato))-

RTECS #

ZH3325000

CAS #

12122-67-7; 142-14-3; 14039-25-9

Updated

June 2017

Molecular Weight

275.73

Molecular Formula

C4H6N2S4·Zn

Synonyms

((1,2-Ethanediylbis(carbamodithioato))(2-))zinc
1,2-Ethanediylbis(carbamodithioato) (2-)-S,S'-zinc
1,2-Ethanediylbiscarbamodithioic acid, zinc complex
Aaphytora
Aspor
Asporum
Bercema
Blightox
Blizene
Carbadine
CHEM zineb
Cineb
Crittox
Cynkotox
Daisen
Devizeb
Dipher
Discon-Z
Dithane 65
Dithane Z
Dithane Z-78
Ditiamina
ENT 14,874
Ethylenebis(dithiocarbamato)zinc
Ethylenebis(dithiocarbamic acid), zinc salt
Hexathane
Kupratsin
Kypzin
Lirotan
Lonacol
Micide
Novosir N
Novozin N 50
Novozir
Novozir N
Novozir N 50
Pamosol 2 forte
Parzate C
Parzate zineb
Perosin
Perosin 75B
Perozin
Perozine
Phytox
Polyram Z
Sperlox-Z
Tanazon
Thiodow
Tiazin
Tiezene
Tritoftorol
Tsineb (Russian)
Zebenide
Zebtox
Zidan
Zinc ethylene-1,2-bisdithiocarbamate
Zinc ethylenebisdithiocarbamate
Zineb
Zineb 75
Zineb 75 WP
Zineb 80
Zink-(N,N'-aethylen-bis(dithiocarbamat)) (German)
Zinosan

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisinhalation/human500 µg/m3/7H/3Y- intermittentGTPZAB 20(12),26,1976
Cytogenetic Analysisoral/mouse10 mg/kgGISAAA 45(1),80,1980
Cytogenetic Analysisother cell types/human0.1 mg/L/48HMUTAEX 16,487,2001
Cytogenetic AnalysisHeLa cell/human5 mg/L/24HMUREAV 536,121,2003
Cytogenetic Analysisfibroblast/human1 mg/L/24HMUREAV 536,121,2003
Cytogenetic Analysisother cell types/human1 mg/L/24HMUREAV 536,121,2003
Cytogenetic Analysisovary/hamster1 mg/L/24HMUREAV 536,121,2003
DNA Damageintraperitoneal/rat50 mg/kgMUREAV 302,1,1993
DNA Damageovary/hamster1 mg/L/80MMUREAV 514,201,2002
DNA Damageleukocyte/rat125 µg/L/1HTXAPA9 211,87,2006
DNA inhibitionother cell types/rat1 mg/LARTODN 45,101,1980
DNA inhibitionlymphocyte/human10 mg/LARTODN 45,101,1980
gene conversion and mitotic recombination/Saccharomyes cerevisiae60 ppmNTIS** PB85-193761
micronucleus testlymphocyte/human25 mg/L/72HEMMUEG 40,57,2002
mutation in microorganisms/Bacillus subtilis1 nmol/plate (-enzymatic activation step)MSERDS 5,93,1981
mutation in microorganisms/Other microorganisms1000 ppm (-enzymatic activation step)MMAPAP 50,233,1973
other mutation test systemsfibroblast/human10 µg/kgGTPZAB 17(3),32,1973
sex chromosome loss and nondisjunctionoral/Drosophila melanogaster50 ppm/4D-continuousMUREAV 206,25,1988
sister chromatid exchangelymphocyte/human10 mg/LGESKAC 12,118,1979
sister chromatid exchangeovary/hamster1 mg/L/24HMUTAEX 18,505,2003
sister chromatid exchangeother cell types/human50 mg/L/72HMUTAEX 16,487,2001
sister chromatid exchangeovary/hamster10 mg/L/36HMUREAV 514,201,2002
specific locus testoral/Drosophila melanogaster50 ppm/4D-continuousMUREAV 206,25,1988

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 20 mg/m3/4H (multigeneration)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)GISAAA 37(8),42,1972
oral/rat 28 gm/kg (6-19D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Musculoskeletal system
NTIS** PB80-181175
oral/rat 4 gm/kg (13D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
FCTXAV 11,239,1973
oral/rat 4 gm/kg (11D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetal death
FCTXAV 11,239,1973
oral/rat 8 gm/kg (9D pregnant)Reproductive: Effects on fertility: Other measures of fertilityEKMMA8 10,226,1971
oral/rat 4 gm/kg (13D pregnant)Reproductive: Specific developmental abnormalities: Eye, earEKMMA8 10,226,1971
oral/rat 8 mg/kg (16D prior to copulation)Reproductive: Maternal effects: Ovaries, fallopian tubesTOERD9 3,279,1981

Tumorigenic Data and References

Route/OrganismDoseEffectReference
implant/rat lowest published toxic dose: 80 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors

Liver: Tumors
VPITAR 29,71,1970
intraperitoneal/mouse lowest published toxic dose: 2600 mg/kg/13W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
VRDEA5 (9),100,1966
intraperitoneal/mouse lowest published toxic dose: 1760 mg/kg (11-21D pregnant)Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Reproductive: Tumorigenic effects: Transplacental tumorigenesis

Lung, Thorax, or Respiration: Tumors
VPITAR 30,49,1971
oral/mouse lowest published toxic dose: 7800 mg/kg/5W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
GISAAA 37(9),25,1972
oral/rat lowest published toxic dose: 273 gm/kg/2.5Y- continuousTumorigenic: Neoplastic by RTECS criteria

Endocrine: Thyroid tumors

Skin and Appendages: Tumors
JTSCDR 4,290,1979
oral/rat lowest published toxic dose: 53580 mg/kg/94W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Gastrointestinal: Colon tumors
VPITAR 29,71,1970

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Hamster, lung fibroblast Inhibitor Concentration Low: 200 µmol/L/1HIn Vitro Toxicity Studies: Other assaysFCTOD7 60,130,2013
inhalation/rat Lowest published lethal concentration: 800 mg/m3/4H85GMAT -,121,1982
intraperitoneal/mouse lethal dose (50 percent kill): 1940 mg/kg85GMAT -,121,1982
intraperitoneal/rat lowest published toxic dose: 70 mg/kgEndocrine: Other changesATSUDG 8,253,1985
oral/human lowest published lethal dose: 5 gm/kg85JFAN A420,1984
oral/mouse lethal dose (50 percent kill): 7600 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Behavioral: Ataxia
JTEHD6 4,93,1978
oral/rabbit lethal dose (50 percent kill): 4450 mg/kg85GMAT -,121,1982
oral/rat lethal dose (50 percent kill): 1850 mg/kgBehavioral: Excitement

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
GISAAA 31(10),25,1966
skin/rat lethal dose (50 percent kill): >2500 mg/kgTXAPA9 14,515,1969
Tank with water/Daphnia lethal concentration (50 percent kill): 0.97 mg/L/48HAQUTO* 7,145,1985
Tank with water/Daphnia lethal concentration (50 percent kill): 89 µg/L/21DAQUTO* 7,165,1985
Tank with water/Daphnia Lowest published lethal concentration: 32 µg/L/21DAQUTO* 7,165,1985
Tank with water/Guppy lethal concentration (50 percent kill): 7.2 mg/L/96HAQUTO* 7,145,1985
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 1350 mg/kgGISAAA 45(5),29,1980
unreported route/rat lethal dose (50 percent kill): 1850 mg/kgEQSSDX 3,618,1975

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lowest published toxic dose: 700 mg/kg/14D- intermittentBiochemical: Neurotransmitters or modulators (putative): Dopamine in striatumNRTXDN 28,727,2007
oral/cattle lowest published toxic dose: 10800 mg/kg/39W- intermittentEndocrine: Evidence of thyroid hypofunction

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Related to Chronic Data: Changes in testicular weight
ATSUDG 12,107,1988
oral/rabbit lowest published toxic dose: 18200 mg/kg/26W- intermittentGastrointestinal: Alteration in gastric secretion

Liver: Liver function tests impaired

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
GISAAA 31(10),25,1966
oral/rabbit lowest published toxic dose: 6231 mg/kg/90D- continuousLiver: Changes in liver weight

Endocrine: Evidence of thyroid hypofunction

Endocrine: Changes in thyroid weight
VHTODE 37,137,1995
oral/rat lowest published toxic dose: 14 gm/kg/2W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainNTIS** PB80-181175
oral/rat lowest published toxic dose: 30 gm/kg/30D- intermittentEndocrine: Other changes

Endocrine: Changes in pituitary weight

Endocrine: Changes in thyroid weight
BECTA6 22,208,1979
oral/rat lowest published toxic dose: 364 gm/kg/2Y- continuousKidney, Ureter, and Bladder: Other changes

Endocrine: Thyroid weight (goiter)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JPETAB 109,159,1953
oral/rat lowest published toxic dose: 1500 mg/kg/5D- intermittentEndocrine: HypoglycemiaBECTA6 56,847,1996

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 12,245,1976
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 12,245,1976
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMSUDL 7,56,1987
TOXICOLOGY REVIEWCNDQA8 10(3),43,1975
TOXICOLOGY REVIEWCNDQA8 14,49,1979
TOXICOLOGY REVIEWMUREAV 557,109,2004
TOXICOLOGY REVIEWMUREAV 562,77,2004
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWENTOX* -,86,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWJTEHD6 7,1,2004
TOXICOLOGY REVIEWJTPAE7 19,1,2006
TOXICOLOGY REVIEWHUTOX* -,561,1996
TOXICOLOGY REVIEWTXCYAC 307,3,2013
TOXICOLOGY REVIEWTXAPA9 268,157,2013
TOXICOLOGY REVIEWFCTOD7 84,133,2015

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,218,1998
Occupational Exposure Limit-GERMANYMAK 0.1 mg(Zn)/m3, inhal, 2011
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.5 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 83787; Number of Industries 1; Total Number of Facilities 291; Number of Occupations 1; Total Number of Employees Exposed 3205
National Occupational Hazard Survey 1974Hazard Code 83787; Number of Industries 1; Total Number of Facilities 12; Number of Occupations 1; Total Number of Employees Exposed 72

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-homozygosis
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
OSHA ANALYTICAL METHOD #107
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