Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

Zinc

RTECS #

ZG8600000

CAS #

7440-66-6

Updated

October 2017

Molecular Weight

65.37

Molecular Formula

Zn

Synonyms

Blue powder
Granular zinc
LS 2
LS 6
Merrillite
Rheinzink
Zinc dust
Zinc powder

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /human 300 µg/3D- intermittent mild85DKA8 -,127,1977

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 12.600 mg/kg/46W- continuousTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Tumorigenic: Facilitates action of known carcinogens
CALEDQ 143,63,1999

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/human lowest published toxic concentration: 124 mg/m3/50MLung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Dyspnea

Skin and Appendages: Other: Sweating
AHYGAJ 72,358,1910
intratracheal/rat lowest published toxic dose: 25 mg/kgLung, Thorax, or Respiration: Tumors

Reproductive: Tumorigenic effects: Testicular tumors
VCVN1* -,151,1988
multiple/non-mammalian species lethal concentration (50 percent kill): 23 gm/m3/24HTXAPA9 197,177,2004
oral/duck lowest published lethal dose: 388 mg/kgAutonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Ataxia

Blood: Changes in leukocyte (WBC) count
JWIDAW 36,111,2000
oral/mouse lowest published lethal dose: 5 gm/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression

Liver: Hepatitis (hepatocellular necrosis), zonal
TOLED5 161,115,2006
oral/mouse lowest published toxic dose: 5 gm/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOLED5 161,115,2006
oral/mouse lowest published lethal dose: 5000 mg/kgGastrointestinal: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli
TOLED5 161,115,2006
oral/mouse lowest published toxic dose: 5000 mg/kgLiver: Other changes

Kidney, Ureter, and Bladder: Changes primarily in glomeruli

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOLED5 161,115,2006
Tank with water/Daphnia lethal concentration (50 percent kill): 160 µg/L/48HTIVIEQ 31,125,1995

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/woman lowest published toxic concentration: 2.4 mg/m3/5Y- intermittentBlood: Normocytic anemia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
VCVN1* -,154,1988
oral/rat lowest published toxic dose: 17920 mg/kg/20W- continuousBlood: Microcytosis with or without anemia

Blood: Changes in spleen

Nutritional and Gross Metabolic: Changes in: Fe
TOLED5 191,15,2009
oral/woman lowest published toxic dose: 70 mg/kg/10W- intermittentBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
TOXID9 72,143,2003

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWQURBAW 7,75,1974
TOXICOLOGY REVIEWADTEAS 5,51,1972
TOXICOLOGY REVIEWFOREAE 7,313,1942
TOXICOLOGY REVIEWKOTTAM 11,1300,1975
TOXICOLOGY REVIEWAMTODM 3,209,1977
TOXICOLOGY REVIEWCREOH* 42,93,2002
TOXICOLOGY REVIEWMAERE* 51,247,2001
TOXICOLOGY REVIEWMUREAV 567,109,2004
TOXICOLOGY REVIEWTPHSDY 23,426,2002
TOXICOLOGY REVIEWCBCPAI 132,269,2002
TOXICOLOGY REVIEWENTOX* -,479,2005
TOXICOLOGY REVIEWREPTED 23,260,2007
TOXICOLOGY REVIEWREPTED 23,428,2007
TOXICOLOGY REVIEWHBTME* ,925,2007
TOXICOLOGY REVIEWHUTOX* -,515,1996
TOXICOLOGY REVIEWHTOPA* 1,595,2002
TOXICOLOGY REVIEWMUREAV 674,73,2009
TOXICOLOGY REVIEWMUREAV 667,82,2009
TOXICOLOGY REVIEWNEUCL* 23,485,2005
TOXICOLOGY REVIEWNTAPM* -,629,1995
TOXICOLOGY REVIEWNTAPM* -,689,1995
TOXICOLOGY REVIEWMUTAEX 27,257,2012
TOXICOLOGY REVIEWTOLED5 198,13,2010
TOXICOLOGY REVIEWMUTAEX 30,89,2014
TOXICOLOGY REVIEWMUREAV 733,1,2012
TOXICOLOGY REVIEWMUREAV 767,67,2016
TOXICOLOGY REVIEWTXCYAC 313,3,2013
TOXICOLOGY REVIEWMUREAV 770,140,I2

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESRED CompletedRBREV* -,346,1998
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 0.1 mg/m3, JAN1993
Occupational Exposure Limit-GERMANYMAK 0.1 mg/m3, resp, 2011
Occupational Exposure Limit-GERMANYMAK 2 mg/m3, inhal, 2011
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 mg/m3, KZG-week 0.4 mg/m3, resp, JAN2011
Occupational Exposure Limit-SWITZERLANDMAK-week 2 mg/m3, KZG-week 4 mg/m3, inhal, JAN2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X4242; Number of Industries 46; Total Number of Facilities 3278; Number of Occupations 47; Total Number of Employees Exposed 79920; Total Number of Female Employees Exposed 7874
National Occupational Exposure Survey 1983Hazard Code X5913; Number of Industries 1; Total Number of Facilities 22; Number of Occupations 2; Total Number of Employees Exposed 269; Total Number of Female Employees Exposed 22
National Occupational Exposure Survey 1983Hazard Code X5990; Number of Industries 2; Total Number of Facilities 42; Number of Occupations 3; Total Number of Employees Exposed 1007; Total Number of Female Employees Exposed 321
National Occupational Exposure Survey 1983Hazard Code X5991; Number of Industries 8; Total Number of Facilities 177; Number of Occupations 18; Total Number of Employees Exposed 10589; Total Number of Female Employees Exposed 3273
National Occupational Exposure Survey 1983Hazard Code 77115; Number of Industries 211; Total Number of Facilities 23711; Number of Occupations 133; Total Number of Employees Exposed 320917; Total Number of Female Employees Exposed 34194
National Occupational Hazard Survey 1974Hazard Code T0146; Number of Industries 2; Total Number of Facilities 44; Number of Occupations 1; Total Number of Employees Exposed 324
National Occupational Hazard Survey 1974Hazard Code 77115; Number of Industries 120; Total Number of Facilities 9450; Number of Occupations 90; Total Number of Employees Exposed 118548

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/100236/AS)
EPA GENETOX PROGRAM 1988, Inconclusive: In vivo cytogenetics-human lymphocyte
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Elements in blood or tissue, 8005
NIOSH Analytical Method, 1994: Metals in urine, 8310
NIOSH Analytical Method, 1994: Zinc and compounds as Zn, 7030
On EPA IRIS database
OSHA ANALYTICAL METHOD #ID121
OSHA ANALYTICAL METHOD #ID125G
TOP