Vinyl fluoride

RTECS #

YZ7351000

CAS #

75-02-5
See: NMAM or OSHA Methods

Updated

March 2018

Molecular Weight

46.05

Molecular Formula

C₂H₃F

Synonyms

Ethene, fluoro-
Ethylene, fluoro- (8CI)
Fluoroethene
Fluoroethylene
Fluoroethylene (IUPAC)
Monofluoroethene
Monofluoroethylene

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
micronucleus test	inhalation/mouse	19100 ppm/6H-continuous	EMMUEG 19(Suppl 20),5,1992
morphological transform	inhalation/rat	2000 ppm/14W- intermittent	ARTODN 47,71,1981

Tumorigenic Data and References

Route/Organism	Dose	Effect	Reference
inhalation/mouse	lowest published toxic concentration: 25 ppm/6H/1.5Y- intermittent	Tumorigenic: Neoplastic by RTECS criteria Lung, Thorax, or Respiration: Tumors Liver: Tumors	NTIS** OTS0538078
inhalation/rat	lowest published toxic concentration: 2500 ppm/6H/2Y- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors Skin and Appendages: Tumors	NTIS** OTS0538078

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	Lethal concentration: >80 pph/12.5H	Behavioral: Altered sleep time (including change in righting reflex) Behavioral: Change in motor activity (specific assay) Lung, Thorax, or Respiration: Dyspnea	AIHOAX 2(3),335,1950
inhalation/rat	lethal concentration (50 percent kill): 1600000 mg/m³/4H		VCVGH* -,286,1990
inhalation/rat	lowest published toxic concentration: 864 mg/m³/30M	Behavioral: General anesthetic	VCVGH* -,286,1990

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/mouse	lowest published toxic concentration: 20000 ppm/6H/13W- intermittent	Olfaction: Other olfaction effects Liver: Other changes Kidney, Ureter, and Bladder: Other changes in urine composition	NTIS** OTS0522820
inhalation/rat	lowest published toxic concentration: 2000 ppm/6H/13W- intermittent	Liver: Other changes Kidney, Ureter, and Bladder: Other changes in urine composition	NTIS** OTS0522820

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 1 ppm	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 2.5 mg(F)/m3	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not classifiable as a human carcinogen	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Suspected human carcinogen	DTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Sufficient Evidence	IMEMDT 63,467,1995
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Sufficient Evidence	IMEMDT 97,469,2008
International Agency for Research on Cancer (IARC)	Cancer Review:Animal No Adequate Data	IMEMDT 39,147,1986
International Agency for Research on Cancer (IARC)	Cancer Review:Human No Adequate Data	IMEMDT 39,147,1986
International Agency for Research on Cancer (IARC)	Cancer Review:Human Inadequate Evidence	IMEMDT 63,467,1995
International Agency for Research on Cancer (IARC)	Cancer Review: Group 2A	IMEMDT 97,469,2008
International Agency for Research on Cancer (IARC)	Cancer Review:Human Inadequate Evidence	IMEMDT 97,469,2008
International Agency for Research on Cancer (IARC)	Cancer Review:Group 3	IMSUDL 7,56,1987
International Agency for Research on Cancer (IARC)	Cancer Review:Group 2A	IMEMDT 97,469,2008
International Agency for Research on Cancer (IARC)	Cancer Review:Group 2A	IMEMDT 63,467,1995
TOXICOLOGY REVIEW		FCTOD7 44,1699,2006
TOXICOLOGY REVIEW		FCTOD7 49,1877,2011

Standards and Regulations

Organization	Standard	Reference
Occupational Exposure Limit-AUSTRALIA	time-weighted average 2.5 mg(F)/m³, JUL2008
Occupational Exposure Limit-BELGIUM	time-weighted average 1 ppm (2 mg/m³), MAR2002
Occupational Exposure Limit-FINLAND	time-weighted average 2.5 mg(F)/m³, NOV2011
Occupational Exposure Limit-GERMANY	MAK 1 mg(F)/m³, inhal, 2011
Occupational Exposure Limit-JAPAN	2A carc, MAY2012
Occupational Exposure Limit-MEXICO	time-weighted average 2.5 mg(F)/m³, 2004

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO VINYL FLUORIDE-air	use 29 Code of Federal Regulations (CFR) 1910.1017	NIOSH* DHHS #92-100,1992

Status in Federal Agencies

Organization	Reference
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, PROPOSED RULE	FEREAC 47,27009,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 14th Report on Carcinogens,2016:Reasonably anticipated to be human carcinogen

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health