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Registry of Toxic Effects of Chemical Substances (RTECS)

Vinyl fluoride

RTECS #

YZ7351000

CAS #

75-02-5

Updated

March 2016

Molecular Weight

46.05

Molecular Formula

C2H3F

Synonyms

Ethene, fluoro-
Ethylene, fluoro- (8CI)
Fluoroethene
Fluoroethylene
Fluoroethylene (IUPAC)
Monofluoroethene
Monofluoroethylene

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
micronucleus testinhalation/mouse19100 ppm/6H-continuousEMMUEG 19(Suppl 20),5,1992
morphological transforminhalation/rat2000 ppm/14W- intermittentARTODN 47,71,1981

Tumorigenic Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 25 ppm/6H/1.5Y- intermittentTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
NTIS** OTS0538078
inhalation/rat lowest published toxic concentration: 2500 ppm/6H/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Skin and Appendages: Tumors
NTIS** OTS0538078

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat Lethal concentration: >80 pph/12.5HBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Dyspnea
AIHOAX 2(3),335,1950
inhalation/rat lethal concentration (50 percent kill): 1600000 mg/m3/4HVCVGH* -,286,1990
inhalation/rat lowest published toxic concentration: 864 mg/m3/30MBehavioral: General anestheticVCVGH* -,286,1990

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 20000 ppm/6H/13W- intermittentOlfaction: Other olfaction effects

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes in urine composition
NTIS** OTS0522820
inhalation/rat lowest published toxic concentration: 2000 ppm/6H/13W- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Other changes in urine composition
NTIS** OTS0522820

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 1 ppmDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 2.5 mg(F)/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Suspected human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 63,467,1995
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 97,469,2008
International Agency for Research on Cancer (IARC)Cancer Review:Animal No Adequate DataIMEMDT 39,147,1986
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 39,147,1986
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 63,467,1995
International Agency for Research on Cancer (IARC)Cancer Review: Group 2AIMEMDT 97,469,2008
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 97,469,2008
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMSUDL 7,56,1987
International Agency for Research on Cancer (IARC)Cancer Review:Group 2AIMEMDT 97,469,2008
International Agency for Research on Cancer (IARC)Cancer Review:Group 2AIMEMDT 63,467,1995
TOXICOLOGY REVIEWFCTOD7 44,1699,2006
TOXICOLOGY REVIEWFCTOD7 49,1877,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRALIAtime-weighted average 2.5 mg(F)/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 1 ppm (2 mg/m3), MAR2002
Occupational Exposure Limit-FINLANDtime-weighted average 2.5 mg(F)/m3, NOV2011
Occupational Exposure Limit-GERMANYMAK 1 mg(F)/m3, inhal, 2011
Occupational Exposure Limit-JAPAN2A carc, MAY2012
Occupational Exposure Limit-MEXICOtime-weighted average 2.5 mg(F)/m3, 2004

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO VINYL FLUORIDE-airuse 29 Code of Federal Regulations (CFR) 1910.1017NIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, PROPOSED RULEFEREAC 47,27009,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
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