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The National Institute for Occupational Safety and Health (NIOSH)

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Registry of Toxic Effects of Chemical Substances (RTECS)

Valeric acid

RTECS #

YV6100000

CAS #

109-52-4

Updated

February 2006

Molecular Weight

102.15

Molecular Formula

C₅H₁₀O₂

Synonyms

1-Butanecarboxylic acid
Butanecarboxylic acid
Kyselina valerova (Czech)
n-Pentanoic acid
n-Valeric acid
Pentanoic acid
Propylacetic acid
Valerianic acid

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
oral/rat	7500 mg/kg (6-15D pregnant)	Reproductive: Other effects on female Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) Reproductive: Specific developmental abnormalities: Musculoskeletal system	NTIS** OTS0571218

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/mouse	lethal concentration (50 percent kill): 4100 mg/m³/2H		85GMAT -,119,1982
intraperitoneal/mouse	lethal dose (50 percent kill): 3590 mg/kg		JPPMAB 21,85,1969
intravenous/mouse	lethal dose (50 percent kill): 1290 mg/kg	Behavioral: Altered sleep time (including change in righting reflex) Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Respiratory depression	APTOA6 18,141,1961
oral/mouse	lethal dose (50 percent kill): 600 mg/kg		85GMAT -,119,1982
subcutaneous/mouse	lethal dose (50 percent kill): 3590 mg/kg		JPPMAB 21,85,1969

Reviews

Organization	Standard	Reference
TOXICOLOGY REVIEW		AMIHAB 21,100,1960

Standards and Regulations

Organization	Standard	Reference
Occupational Exposure Limit-RUSSIA	short term exposure limit 5 mg/m³, JUN2003

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Occupational Exposure Survey 1983	Hazard Code 84212; Number of Industries 2; Total Number of Facilities 79; Number of Occupations 8; Total Number of Employees Exposed 4510; Total Number of Female Employees Exposed 780
National Occupational Hazard Survey 1974	Hazard Code 84212; Number of Industries 1; Total Number of Facilities 21; Number of Occupations 3; Total Number of Employees Exposed 497

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

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Page last reviewed:March 7, 2014
Page last updated:February 6, 2017
Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division

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