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Registry of Toxic Effects of Chemical Substances (RTECS)

Urea, 1-(1-naphthyl)-2-thio-

RTECS #

YT9275000

CAS #

86-88-4

Updated

September 2013

Molecular Weight

202.29

Molecular Formula

C11H10N2S

Synonyms

1-(1-Naphthyl)-2-thiourea
1-Naftil-tiourea (Italian)
1-Naftylthioureum (Dutch)
1-Naphthalenylthiourea
1-Naphthyl thiourea
1-Naphthyl-thioharnstoff (German)
1-Naphthyl-thiouree (French)
alpha-Naftylthiomocovina (Czech)
alpha-Naphthalthioharnstoff (German)
alpha-Naphthothiourea
Alphanaphthyl thiourea
alpha-Naphthylthiocarbamide
alpha-Naphthylthiourea
alpha-Naphthylthiourea (DOT:OSHA)
Alphanaphtyl thiouree (French)
Alrato
ANTU
ANTU (ACGIH:OSHA)
Anturat
Bantu
Chemical 109
Dirax
Kill kantz
Krysid
Krysid PI
N-(1-Naphthyl)-2-thiourea
Naphtox
Rattrack
Rat-TU
RCRA waste number P072
Smeesana
Thiourea, 1-naphthalenyl-
U-5227
USAF EK-P-5976

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
morphological transformembryo/hamster1600 µg/LNCIMAV 58,243,1981
mutation in microorganisms/Salmonella typhimurium500 nmol/L (-enzymatic activation step)ENMUDM 3,11,1981

Tumorigenic Data and References

Route/OrganismDoseEffectReference
subcutaneous/mouse lowest published toxic dose: 5 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Blood: Tumors
NTIS** PB223-159

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/chicken lethal dose (50 percent kill): 2500 mg/kgPSEBAA 62,22,1946
intraperitoneal/Dog lethal dose (50 percent kill): 16 mg/kgENTOX* -,188,2005
intraperitoneal/guinea pig lethal dose (50 percent kill): 350 mg/kgPSEBAA 62,22,1946
intraperitoneal/monkey lethal dose (50 percent kill): 175 mg/kgPSEBAA 62,22,1946
intraperitoneal/mouse lethal dose (50 percent kill): 10 mg/kgNTIS** AD277-689
intraperitoneal/rat lethal dose (50 percent kill): 2470 µg/kgLung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Pleural effusion
JPETAB 97,432,1949
oral/cat lethal dose (50 percent kill): 500 mg/kgPSEBAA 62,22,1946
oral/chicken lethal dose (50 percent kill): 4250 mg/kgPSEBAA 62,22,1946
oral/Dog lethal dose (50 percent kill): 380 µg/kgENTOX* -,188,2005
oral/monkey lethal dose (50 percent kill): 4250 mg/kg85DPAN -,-,1971/1976
oral/mouse lethal dose (50 percent kill): 5 mg/kgYKYUA6 28,329,1977
oral/pig lowest published lethal dose: 50 mg/kgYKYUA6 28,329,1977
oral/rat lethal dose (50 percent kill): 6 mg/kgAFDOAQ 16,47,1952
unreported route/chicken lethal dose (50 percent kill): 700 mg/kg30ZDA9 -,238,1971
unreported route/man lowest published lethal dose: 588 mg/kg85DCAI 2,73,1970
unreported route/monkey lethal dose (50 percent kill): >2 gm/kgBCFAAI 97,289,1958
unreported route/rabbit lethal dose (50 percent kill): >200 mg/kgBCFAAI 97,289,1958

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.3 mg/m3 (skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 30,347,1983
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 30,347,1983
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMSUDL 7,263,1987
TOXICOLOGY REVIEWADCSAJ 13,271,1970
TOXICOLOGY REVIEWENTOX* -,188,2005

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.3 mg/m3DTLVS* 3,14,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.3 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.3 mg/m3;KZW 1.5 mg/m3, inhal, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.3 mg/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.3 mg/m3, carc, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.3 mg/m3, short term exposure limit 0.9 mg/m3, NOV2011
Occupational Exposure Limit-FRANCEVME 0.3 mg/m3, C3 Carcinogen, FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 0.3 mg/m3, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 0.3 mg/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.3 mg/m3;short term exposure limit 0.9 mg/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.3 mg/m3, JAN2002
Occupational Exposure Limit-PERUtime-weighted average 0.3 mg/m3, JUL2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.3 mg/m3, KZG-week 0.6 mg/m3, carc 3, inhal, skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.3 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.3 mg/m3, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 0.3 mg/m3, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.3 mg/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.3 mg/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.3 mg/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.3 mg/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ANTU-air10H time-weighted average 0.3 mg/m3NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code M0294; Number of Industries 1; Total Number of Facilities 25; Number of Occupations 4; Total Number of Employees Exposed 1450

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Positive: SHE-clonal assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
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