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Registry of Toxic Effects of Chemical Substances (RTECS)

Triethylene glycol

RTECS #

YE4550000

CAS #

112-27-6

Updated

October 2014

Molecular Weight

150.20

Molecular Formula

C6H14O4

Synonyms

1,2-Bis(2-hydroxyethoxy)ethane
2,2'-(1,2-Ethanediylbis(oxy))bisethanol
2,2'-Ethylenedioxybis(ethanol)
2,2'-Ethylenedioxydiethanol
2,2'-Ethylenedioxyethanol
3,6-Dioxaoctane-1,8-diol
Di-beta-hydroxyethoxyethane
Ethanol, 2,2'-(ethylenedioxy)di-
Ethylene glycol dihydroxydiethyl ether
Ethylene glycol-bis-(2-hydroxyethyl ether)
Glycol bis(hydroxyethyl) ether
TEG
Triethylenglykol (Czech)
Trigen
Triglycol

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 500 mg mildAJOPAA 29,1363,1946
skin /rabbit 500 mg/24H mildFCTXAV 17,913,1979

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
heritable translocation testskin/Drosophila melanogaster1.32 mmol/LTOXID9 78,265,2004

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 103 gm/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
EPASR* 8EHQ-1190-1064
oral/mouse 90160 mg/kg (7-14D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)EVHPAZ 57,141,1984
oral/mouse 323 gm/kg (multigeneration)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)FAATDF 18,602,1992
oral/mouse 57820 mg/kg (multigeneration)Reproductive: Effects on newborn: PhysicalFAATDF 18,602,1992
oral/mouse 90160 mg/kg (7-14D pregnant)Reproductive: Effects on newborn: Other neonatal measures or effectsEVHPAZ 57,141,1984
oral/rat 300 mg/kg (1D male)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)VCVGK* -,146,1994
oral/mouse 6.8 gm/kg (multigenerations)Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Effects on newborn: Other postnatal measures or effects
NTIS** #PB88204300
oral/mouse 115.5 gm/kg (7D male/7D prior to copulation/21D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)NTIS** #PB88204300
oral/mouse 56300 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
JAPTO* 25,418,2005

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic dose: 4545 mg/m3/30MLung, Thorax, or Respiration: Respiratory depressionJJATDK 26,387,2006
inhalation/rat lowest published toxic dose: 5020 mg/m3/4HPeripheral Nerve and Sensation: Sensory change involving peripheral nerve

Eye: Conjunctiva irritation

Eye: Other eye effects
JJATDK 26,387,2006
inhalation/rat lethal concentration (50 percent kill): >4400 mg/m3/4HJAPTO* 27,291,2007
intramuscular/rat lowest published lethal dose: 8400 mg/kgNutritional and Gross Metabolic: Body temperature decreaseJAPMA8 29,5,1940
intraperitoneal/mouse lethal dose (50 percent kill): 8141 mg/kgLung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli

Blood: Changes in spleen
FEPRA7 6,342,1947
intraperitoneal/mouse lethal dose (50 percent kill): 8141 mg/kgJAPTO* 27,291,2007
intravenous/Dog lethal dose (50 percent kill): >4500 mg/kgJAPTO* 27,291,2007
intravenous/guinea pig lethal dose (50 percent kill): 10600 mg/kgARZNAD 18,1536,1968
intravenous/mouse lethal dose (50 percent kill): 6500 mg/kgJAPTO* 27,291,2007
intravenous/rabbit lethal dose (50 percent kill): 1900 mg/kgJAPTO* 27,291,2007
intravenous/rat lethal dose (50 percent kill): 11700 mg/kgJAPTO* 27,291,2007
oral/guinea pig lethal dose (50 percent kill): 7900 mg/kgLiver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,146,1984
oral/guinea pig lethal dose (50 percent kill): 7900 mg/kgJAPTO* 27,291,2007
oral/human lowest published lethal dose: 5 gm/kgFCTXAV 17,913,1979
oral/mammal (species unspecified) lethal dose (50 percent kill): 8150 mg/kgGISAAA 39(4),86,1974
oral/mouse lethal dose (50 percent kill): 20000 mg/kgLiver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,146,1984
oral/mouse lowest published lethal dose: 18500 mg/kgPCOC** -,1186,1966
oral/mouse lethal dose (50 percent kill): >18500 mg/kgJAPTO* 27,291,2007
oral/rabbit lethal dose (50 percent kill): 8400 mg/kgJAPTO* 27,291,2007
oral/rabbit lethal dose (50 percent kill): 8400 mg/kgLiver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,146,1984
oral/rat lethal dose (50 percent kill): 17 gm/kgJIHTAB 28,40,1946
oral/rat lethal dose (50 percent kill): 15000 mg/kgLiver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,146,1984
skin/rabbit lethal dose (50 percent kill): >20 mL/kg34ZIAG -,731,1969
skin/rabbit lowest published lethal dose: 16 mL/kg/24HJAPTO* 27,291,2007
subcutaneous/mouse lethal dose (50 percent kill): 8750 mg/kgJPETAB 65,89,1939
unreported route/human lowest published lethal dose: 5000 mg/kgVCVGK* -,146,1984

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 4824 mg/m3/12H/2D- intermittentBehavioral: Ataxia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JJATDK 26,387,2006
inhalation/rat lowest published toxic concentration: 2011 mg/m3/12H/2D- intermittentEye: Other eye effectsJJATDK 26,387,2006
inhalation/rat lowest published toxic concentration: 2011 mg/m3/30H/5D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainJJATDK 26,387,2006
inhalation/rat lowest published toxic concentration: 494 mg/m3/54H/11D- intermittentBehavioral: Food intake (animal)

Behavioral: Fluid intake
JJATDK 26,387,2006
inhalation/rat lowest published toxic concentration: 2011 mg/m3/48H/10D- intermittentBehavioral: Fluid intakeJJATDK 26,387,2006
inhalation/rat lowest published toxic concentration: 2011 mg/m3/54H/11D- intermittentKidney, Ureter, and Bladder: Urine volume increased

Kidney, Ureter, and Bladder: Other changes in urine composition

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
JJATDK 26,387,2006
inhalation/rat lowest published toxic concentration: 494 mg/m3/54H/11D- intermittentNutritional and Gross Metabolic: Changes in: P

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
JJATDK 26,387,2006
inhalation/rat lowest published toxic concentration: 2011 mg/m3/54H/11D- intermittentLung, Thorax, or Respiration: Other changes

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight
JJATDK 26,387,2006
inhalation/rat lowest published toxic concentration: 494 mg/m3/9D- intermittentBehavioral: Fluid intake

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
JAPTO* 27,291,2007
inhalation/rat lowest published toxic concentration: 2011 mg/m3/9D- intermittentBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
JAPTO* 27,291,2007
inhalation/rat lowest published toxic concentration: 4824 mg/m3/2D- intermittentBehavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JAPTO* 27,291,2007
oral/mouse lowest published toxic dose: 33780 mg/kg/3D- intermittentBehavioral: Somnolence (general depressed activity)

Behavioral: Fluid intake

Lung, Thorax, or Respiration: Dyspnea
JAPTO* 25,418,2005
oral/mouse lowest published toxic dose: 112600 mg/kg/10D- intermittentKidney, Ureter, and Bladder: Changes in kidney weightJAPTO* 25,418,2005
oral/mouse lowest published toxic dose: 90160 mg/kg/8D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldEVHPAZ 57,141,1984
oral/rat lowest published toxic dose: 910 mg/kg/26W- intermittentLiver: Multiple effects

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,146,1994
oral/rat lowest published toxic dose: 910 mg/kg/26W- intermittentBlood: Changes in bone marrow not included in above

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
VCVGK* -,147,1994
oral/rat lowest published toxic dose: 17.5 gm/kg/7D- continuousBehavioral: Food intake (animal)VHTODE 43,269,2001
oral/rat lowest published toxic dose: 42 gm/kg/14D- continuousBehavioral: Food intake (animal)

Kidney, Ureter, and Bladder: Urine volume increased
VHTODE 43,269,2001
oral/rat lowest published toxic dose: 35 gm/kg/14D- continuousKidney, Ureter, and Bladder: Urine volume increasedVHTODE 43,269,2001
oral/rat lowest published toxic dose: 140 gm/kg/8W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainVHTODE 43,269,2001
oral/rat lowest published toxic dose: 45 gm/kg/90D- continuousBrain and Coverings: Changes in brain weightVHTODE 43,269,2001
oral/rat lowest published toxic dose: 67320 mg/kg/90D- intermittentKidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Changes in kidney weight
JAPTO* 27,291,2007
oral/rat lowest published toxic dose: 136980 mg/kg/90D- intermittentKidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Changes in kidney weight

Blood: Changes in erythrocyte (RBC) count
JAPTO* 27,291,2007
oral/rat lowest published toxic dose: 215544 mg/kg/56D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainJAPTO* 27,291,2007
oral/rat lowest published toxic dose: 436410 mg/kg/90D- intermittentKidney, Ureter, and Bladder: Urine volume decreased or anuria

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JAPTO* 27,291,2007
oral/rat lowest published toxic dose: 152910 mg/kg/90D- intermittentKidney, Ureter, and Bladder: Urine volume decreased or anuria

Kidney, Ureter, and Bladder: Changes in kidney weight
JAPTO* 27,291,2007
oral/rat lowest published toxic dose: 392400 mg/kg/90D- intermittentKidney, Ureter, and Bladder: Urine volume decreased or anuria

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JAPTO* 27,291,2007
oral/rat lowest published toxic dose: 33780 mg/kg/3D- intermittentBehavioral: Fluid intake

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JAPTO* 25,418,2005
oral/rat lowest published toxic dose: 112600 mg/kg/10D- intermittentKidney, Ureter, and Bladder: Changes in kidney weightJAPTO* 25,418,2005
oral/rat lowest published toxic dose: 56300 mg/kg/10D- intermittentBehavioral: Fluid intakeJAPTO* 25,418,2005
oral/rat lowest published toxic dose: 455 mg/kg/13W- intermittentLiver: Other changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
GISAAA 52(11),86,1987
oral/rat lowest published toxic dose: 650 mg/kg/26W- intermittentLiver: Liver function tests impaired

Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
GISAAA 52(12),77,1987

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWFAATDF 13,747,1989
TOXICOLOGY REVIEWTOLED5 199,203,2010

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,283,1998
Occupational Exposure Limit-GERMANYMAK 1000 mg/m3, inhal, 2011
Occupational Exposure Limit-RUSSIAshort term exposure limit 10 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 1000 mg/m3, KZG-week 2000 mg/m3, inhal, JAN2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 80354; Number of Industries 119; Total Number of Facilities 23174; Number of Occupations 100; Total Number of Employees Exposed 233613; Total Number of Female Employees Exposed 53367
National Occupational Hazard Survey 1974Hazard Code 80354; Number of Industries 120; Total Number of Facilities 18128; Number of Occupations 97; Total Number of Employees Exposed 146703

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1996: Glycols, 5523
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