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Registry of Toxic Effects of Chemical Substances (RTECS)

p-Toluidine

RTECS #

XU3150000

CAS #

106-49-0

Updated

September 2013

Molecular Weight

107.17

Molecular Formula

C7H9N

Synonyms

1-Amino-4-methylbenzene
4-Amino-1-methylbenzene
4-Aminotoluen (Czech)
4-Aminotoluene
4-Methylaniline
4-Methylbenzenamine
4-Toluidine
Aniline, p-methyl-
Benzenamine, 4-methyl- (9CI)
C.I. 37107
C.I. Azoic Coupling Component 107
Naphtol AS-KG
Naphtol AS-KGLL
p-Aminotoluene
p-Methylaniline
p-Methylbenzenamine
p-Toluidin (Czech)
p-Toluidine (ACGIH)
p-Toluidyna (Polish)
p-Tolylamine
RCRA waste number U353
Tolylamine

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 20 mg/24H moderate85JCAE -,460,1986
eye /rabbit 0.1 gm moderateHPV300 -,-,2001
skin /rabbit 500 mg/24H mild85JCAE -,460,1986

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damageintraperitoneal/mouse35 mg/kgATSUDG 5,355,1982
DNA inhibitionoral/mouse200 mg/kgHPV300 -,-,2001
Unscheduled DNA Synthesisliver/rat100 µmol/LENMUDM 5,803,1983

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 64800 mg/kg/72W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
HPV300 -,-,2001

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): 640 mg/m3/1HHPV300 -,-,2001
intraperitoneal/mouse lethal dose (50 percent kill): 50 mg/kgHPV300 -,-,2001
oral/mouse lethal dose (50 percent kill): 330 mg/kgENTOX* -,206,2005
oral/quail lethal dose (50 percent kill): 237 mg/kgAECTCV 12,355,1983
oral/rabbit lethal dose (50 percent kill): 270 mg/kgHPV300 -,-,2001
oral/rat lethal dose (50 percent kill): 336 mg/kgPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
BCTKAG 17,51,1984
oral/rat lethal dose (50 percent kill): 620 mg/kgHPV300 -,-,2001
oral/wild bird lethal dose (50 percent kill): 42 mg/kgTXAPA9 21,315,1972
skin/rabbit lethal dose (50 percent kill): 890 mg/kgHPV300 -,-,2001
subcutaneous/rat lethal dose (50 percent kill): 1012 mg/kgHPV300 -,-,2001

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lowest published toxic dose: 225 mg/kg/3D- continuousLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
HPV300 -,,2001
oral/mouse lowest published toxic dose: 3075 mg/kg/3D- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldHPV300 -,,2001
oral/rat lowest published toxic dose: 4560 mg/kg/30D- intermittentKidney, Ureter, and Bladder: Proteinuria

Blood: Normocytic anemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VINIT* #4035-77
oral/rat lowest published toxic dose: 1722 mg/kg/6W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainIJTOFN 24,365,2005
oral/rat lowest published toxic dose: 2086 mg/kg/2W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainIJTOFN 24,365,2005
oral/rat lowest published toxic dose: 1230 mg/kg/30D- continuousLiver: Other changes

Blood: Methemoglobinemia- Carboxhemoglobinemia
IJTOFN 24,365,2005
oral/rat lowest published toxic dose: 1870 mg/kg/4W- continuousLiver: Changes in liver weightHPV300 -,,2001
oral/rat lowest published toxic dose: 3519 mg/kg/4W- continuousLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV300 -,,2001

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 2 ppm (skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWENTOX* -,206,2005

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 2 ppm (8.8 mg/m3), Carcinogen, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.2 ppm (1 mg/m3);KZW 0.8 ppm (4 mg/m3), skin, sen, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 2 ppm (8.9 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 2 ppm (9 mg/m3), skin, carc, MAY2011
Occupational Exposure Limit-HUNGARYtime-weighted average 1 mg/m3, short term exposure limit 4 mg/m3, Skin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 2 ppm (9 mg/m3), skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 2 ppm (9 mg/m3), skin, 2006
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 2 ppm (8.8 mg/m3), skin, JAN2002
Occupational Exposure Limit-PERUtime-weighted average 2 ppm (8,8 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 1 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 0.2 ppm, carc 3, skin, sen, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 9 mg/m3, Skin, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO p-TOLUIDINE-airCarcinogen lowest feasible conc. (Sk)NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code M0854; Number of Industries 4; Total Number of Facilities 206; Number of Occupations 2; Total Number of Employees Exposed 428; Total Number of Female Employees Exposed 87
National Occupational Hazard Survey 1974Hazard Code M0854; Number of Industries 8; Total Number of Facilities 508; Number of Occupations 5; Total Number of Employees Exposed 2267

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: E coli polA without S9; E coli polA with S9
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #ID-73
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