Thiosulfuric acid, disodium salt

RTECS #
XN6476000
CAS #
7772-98-7
See: NMAM or OSHA Methods
Updated
June 2018
Molecular Weight
158.10
Molecular Formula
O3S2·2Na
Synonyms
Chlorine Control
Chlorine Cure
Declor-It
Disodium thiosulfate
S-Hydril
Sodium hyposulfite
Sodium oxide sulfide (Na2S2O3)
Sodium thiosulfate
Sodium thiosulfate anhydrous
Sodium thiosulphate (Na2S2O3)
Sodothiol

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisintravenous/rat1500 mg/kgVOONC* -,1132,1992

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, kidney Inhibitor Concentration (20 percent kill): >100 µmol/L/2HIn Vitro Toxicity Studies: Cell metabolic activity: Alamar Blue assay etc.TIVIEQ 40,66,2017
In Vitro/Human, kidney Inhibitor Concentration (20 percent kill): >100 µmol/L/2HEndocrine: Other changesTIVIEQ 40,66,2017
intraperitoneal/mouse lethal dose (50 percent kill): 5200 mg/kgNYKZAU 53,404,1957
intravenous/Dog lethal dose (50 percent kill): 3 gm/kgNutritional and Gross Metabolic: Changes in: NaFEREAC 68,66416,2003
intravenous/mouse lethal dose (50 percent kill): 1.19 gm/kgNutritional and Gross Metabolic: Changes in: NaFEREAC 68,66416,2003
intravenous/rat lethal dose (50 percent kill): >2500 mg/kgNutritional and Gross Metabolic: Changes in: NaFEREAC 68,66416,2003
intravenous/rat Lethal dose: >2500 mg/kgBehavioral: Convulsions or effect on seizure thresholdJPETAB 25,297,1925
oral/rat lethal dose (50 percent kill): >5000 mg/kgFEREAC 68,66416,2003
subcutaneous/frog lowest published lethal dose: 6 gm/kgAIPTAK 5,161,1899
subcutaneous/rabbit lowest published lethal dose: 4 gm/kgAIPTAK 5,161,1899
unreported route/mouse lowest published toxic dose: 800 mg/kgImmunological Including Allergic: Decreased immune responseEKFAE9 61,56,1998
unreported route/rat lowest published toxic dose: 800 mg/kgImmunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Decrease in humoral immune response
EKFAE9 61,56,1998

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intravenous/woman lowest published toxic dose: 0.5 gm/kg/5D- intermittentNutritional and Gross Metabolic: Changes in: Metabolic acidosisCTOXAO 47,754,2009

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 10 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 80153; Number of Industries 118; Total Number of Facilities 13359; Number of Occupations 89; Total Number of Employees Exposed 143967; Total Number of Female Employees Exposed 55082
National Occupational Hazard Survey 1974Hazard Code 80153; Number of Industries 107; Total Number of Facilities 11199; Number of Occupations 62; Total Number of Employees Exposed 61158

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
Page last reviewed: November 16, 2018