Thiophene

RTECS #
XM7350000
CAS #
110-02-1
See: NMAM or OSHA Methods
Updated
February 2006
Molecular Weight
84.14
Molecular Formula
C4H4S
Synonyms
CP 34
Divinylene sulfide
Huile H50
Huile HSO
Thiacyclopentadiene
Thiaphene
Thiofen (Czech)
Thiofuram
Thiofuran
Thiofurfuran
Thiole
Thiophen
Thiotetrole
USAF EK-1860

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 9500 mg/m3/2HGTPZAB 10(2),57,1966
inhalation/rat Lowest published lethal concentration: 2000 ppm/6HTOXID9 8,141,1988
intraperitoneal/mouse lethal dose (50 percent kill): 100 mg/kgNTIS** AD277-689
oral/mouse lethal dose (50 percent kill): 420 mg/kgGTPZAB 10(2),57,1966
oral/rat lethal dose (50 percent kill): 1400 mg/kgGTPZAB 10(2),57,1966
skin/guinea pig lethal dose (50 percent kill): >20 mL/kgNTIS** OTS0555960
subcutaneous/rabbit lethal dose (50 percent kill): 830 mg/kg85JCAE -,1089,1986

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 1010 mg/m3/6H/21W- intermittentLiver: Liver function tests impaired

Endocrine: Evidence of thyroid hyperfunction
GTPZAB 10(2),57,1966
inhalation/rabbit lowest published toxic concentration: 1010 mg/m3/6H/21W- intermittentLiver: Liver function tests impaired

Endocrine: Evidence of thyroid hyperfunction
GTPZAB 10(2),57,1966
inhalation/rat lowest published toxic concentration: 3 mg/m3/24H/80D- continuousBehavioral: Muscle contraction or spasticity

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Endocrine: Other changes
GISAAA 32(6),3,1967
inhalation/rat lowest published toxic concentration: 1010 mg/m3/6H/21W- intermittentLiver: Liver function tests impaired

Endocrine: Evidence of thyroid hyperfunction
GTPZAB 10(2),57,1966
inhalation/rat lowest published toxic concentration: 1600 ppm/6H/15D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0555960
oral/rat lowest published toxic dose: 9500 mg/kg/19D- intermittentBehavioral: Food intake (animal)

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0555960

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWATORAI -,-,1948

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 20 mg/m3, JUN2003

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8861
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
Page last reviewed: November 16, 2018