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Registry of Toxic Effects of Chemical Substances (RTECS)

Succinonitrile

RTECS #

WN3850000

CAS #

110-61-2

Updated

July 2016

Molecular Weight

80.10

Molecular Formula

C4H4N2

Synonyms

Butanedinitrile
Deprelin
Dinile
Ethane, 1,2-dicyano-
Ethylene cyanide
Ethylene dicyanide
s-Dicyanoethane
Succinic acid dinitrile
Succinic dinitrile
Succinodinitrile
Sukcinonitril (Czech)
Suxil
USAF A-9442

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/hamster 365 mg/kg (8D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Central nervous system
FAATDF 3,41,1983

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat Lowest published lethal concentration: 730 mg/m3/4HBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Acute pulmonary edema
NTIS** OTS0570875
intraperitoneal/mouse lethal dose (50 percent kill): 63110 µg/kgKidney, Ureter, and Bladder: Other changes in urine compositionBCPCA6 27,1135,1978
intraperitoneal/rat lethal dose (50 percent kill): 835.5 mg/kg/24HBehavioral: Convulsions or effect on seizure threshold

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Respiratory depression
FCTOD7 59,595,2013
oral/mouse lethal dose (50 percent kill): 129 mg/kgARTODN 57,88,1985
oral/rat lethal dose (50 percent kill): 450 mg/kg38MKAJ 2C,4879,1982
oral/rat lethal dose (50 percent kill): 488.7 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression
FCTOD7 47,2314,2009
oral/rat lethal dose (50 percent kill): 378.5 mg/kg/24HBehavioral: Convulsions or effect on seizure threshold

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Respiratory depression
FCTOD7 59,595,2013
subcutaneous/Dog lowest published lethal dose: 150 mg/kgBehavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Nausea or vomiting
AIPTAK 3,77,1897
subcutaneous/frog lowest published lethal dose: 1 gm/kgAIPTAK 3,77,1897
subcutaneous/pigeon lowest published lethal dose: 2200 mg/kgBehavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Nausea or vomiting
AIPTAK 3,77,1897
subcutaneous/rabbit lowest published lethal dose: 36 mg/kgPeripheral Nerve and Sensation: Spastic paralysis with/without sensory changeAIPTAK 3,77,1897
subcutaneous/rat lethal dose (50 percent kill): 755.2 mg/kg/24HBehavioral: Convulsions or effect on seizure threshold

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Respiratory depression
FCTOD7 59,595,2013

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 726,91,2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO SUCCINONITRILE-air10H time-weighted average 6 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code X5846; Number of Industries 1; Total Number of Facilities 44; Number of Occupations 3; Total Number of Employees Exposed 1440

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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