Sodium(I) nitrate (1:1)
RTECS #
WC5600000
CAS #
Updated
June 2018
Molecular Weight
85.00
Molecular Formula
NO3·Na
Synonyms
Chile saltpeter
Cubic niter
Nitrate de sodium (French)
Nitratine
Nitric acid, sodium salt
Soda niter
Sodium nitrate
Sodium saltpeter
Cubic niter
Nitrate de sodium (French)
Nitratine
Nitric acid, sodium salt
Soda niter
Sodium nitrate
Sodium saltpeter
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
Cytogenetic Analysis | oral/rat | 78500 µg/kg | MUREAV 155,121,1985 |
Cytogenetic Analysis | oral/mouse | 7067 mg/kg | MUREAV 155,121,1985 |
Cytogenetic Analysis | fibroblast/hamster | 7200 mg/L/48H | MUREAV 48,337,1977 |
Cytogenetic Analysis | lung/hamster | 5700 mg/L | GMCRDC 27,95,1981 |
host-mediated assay | embryo/hamster | 125 mg/kg | MUREAV 66,149,1979 |
micronucleus test | oral/hamster | 250 mg/kg | MUREAV 66,149,1979 |
micronucleus test | oral/mouse | 78500 µg/kg | MUREAV 155,121,1985 |
morphological transform | oral/rat | 13 gm/kg/6W | CRNGDP 9,387,1988 |
morphological transform | oral/hamster | 250 mg/kg | MUREAV 66,149,1979 |
mutation in microorganisms | /Other microorganisms | 1000 ppm (-enzymatic activation step) | POASAD 34,114,1953 |
phage inhibition capacity | /Escherichia coli | 133 µg/well | MUREAV 260,349,1991 |
sperm morphology | oral/mouse | 16800 mg/kg/2W | MUREAV 204,689,1988 |
Unscheduled DNA Synthesis | HeLa cell/human | 6 mmol/L | AEMBAP 177,269,1984 |
Reproductive Effects Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
oral/mouse | 16800 mg/kg (14D male) | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | MUREAV 204,689,1988 |
Tumorigenic Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
oral/rat | lowest published toxic dose: 100 gm/kg/2Y- continuous | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Liver: Tumors | FCTOD7 22,715,1984 |
oral/rat | toxic dose: 1825 gm/kg/2Y- continuous | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Skin and Appendages: Tumors Reproductive: Tumorigenic effects: Testicular tumors | FCTOD7 20,25,1982 |
oral/rat | toxic dose: 913 gm/kg/2Y- continuous | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Skin and Appendages: Tumors Reproductive: Tumorigenic effects: Testicular tumors | FCTOD7 20,25,1982 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
In Vitro/Human, kidney | Inhibitor Concentration (50 percent kill): 612.6 µmol/L/2H | Endocrine: Other changes | TIVIEQ 40,66,2017 |
In Vitro/Human, kidney | Inhibitor Concentration (20 percent kill): >100 µmol/L/2H | In Vitro Toxicity Studies: Cell metabolic activity: Alamar Blue assay etc. | TIVIEQ 40,66,2017 |
In Vitro/Human, kidney | Inhibitor Concentration (20 percent kill): >100 µmol/L/2H | Endocrine: Other changes | TIVIEQ 40,66,2017 |
In Vitro/Human, liver tumor | Inhibitor Concentration (50 percent kill): 125 mmol/L/24H | In Vitro Toxicity Studies: Cell protein synthesis | TIVIEQ 3,189,1989 |
intraperitoneal/rat | Lethal dose: >181 mg/kg | TXAPA9 5,750,1963 | |
intravenous/mouse | lethal dose (50 percent kill): 175 mg/kg | ATXKA8 21,89,1965 | |
oral/child | lowest published lethal dose: 22500 µg/kg | Blood: Methemoglobinemia- Carboxhemoglobinemia | JTCTDW 32,173,1994 |
oral/mouse | lethal dose (50 percent kill): 3500 mg/kg | VCVN5* -,49,1993 | |
oral/pig | lowest published toxic dose: 0.5 gm/kg | Behavioral: Change in psychophysiological tests Behavioral: Food intake (animal) Blood: Methemoglobinemia- Carboxhemoglobinemia | GISAAA -,30,1993 |
oral/rabbit | lethal dose (50 percent kill): 2680 mg/kg | SOVEA7 27,246,1974 | |
oral/rat | lethal dose (50 percent kill): 1267 mg/kg | GISAAA 46(12),66,1981 | |
oral/rat | lowest published toxic dose: 1600 mg/kg | Blood: Methemoglobinemia- Carboxhemoglobinemia | TOVEFN (5),22,1996 |
oral/woman | lowest published toxic dose: 14 mg/kg | Cardiac: Pulse rate increased without fall in BP Lung, Thorax, or Respiration: Cyanosis Blood: Methemoglobinemia- Carboxhemoglobinemia | JTCTDW 32,173,1994 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
oral/pig | lowest published toxic dose: 3.5 gm/kg/1W- continuous | Blood: Methemoglobinemia- Carboxhemoglobinemia | GISAAA -,30,1993 |
oral/pig | lowest published toxic dose: 28 gm/kg/8W- continuous | Gastrointestinal: Gastritis | GISAAA -,30,1993 |
oral/rat | lowest published toxic dose: 1224 mg/kg/30D- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases | VCVN5* -,50,1989 |
oral/rat | lowest published toxic dose: 3000 mg/kg/60D- intermittent | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | FCTOD7 48,572,2010 |
oral/rat | lowest published toxic dose: 6000 mg/kg/60D- intermittent | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects Related to Chronic Data: Changes in testicular weight | FCTOD7 48,572,2010 |
oral/rat | lowest published toxic dose: 118 gm/kg/39W- continuous | Liver: Changes in liver weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) | TOLED5 17,125,1983 |
oral/rat | lowest published toxic dose: 386 gm/kg/61W- continuous | Lung, Thorax, or Respiration: Changes in lung weight Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TOLED5 6,199,1980 |
Reviews
Organization | Standard | Reference |
---|---|---|
International Agency for Research on Cancer (IARC) | Cancer Review:Animal Inadequate Evidence | IMEMDT 94,325,2010 |
International Agency for Research on Cancer (IARC) | Cancer Review:Human Inadequate Evidence | IMEMDT 94,325,2010 |
International Agency for Research on Cancer (IARC) | Cancer Review:Group 2A | IMEMDT 94,325,2010 |
TOXICOLOGY REVIEW | TXAPA9 243,180,2010 | |
TOXICOLOGY REVIEW | MUREAV 721,27,2011 | |
TOXICOLOGY REVIEW | TOLED5 200,107,2011 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 | |
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES | RED Completed | RBREV* -,318,1998 |
Occupational Exposure Limit-RUSSIA | short term exposure limit 5 mg/m3, JUN2003 |
NIOSH Documentation and Surveillance
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health