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Registry of Toxic Effects of Chemical Substances (RTECS)

Sodium(I) nitrate (1:1)

RTECS #

WC5600000

CAS #

7631-99-4

Updated

October 2012

Molecular Weight

85.00

Molecular Formula

NO₃·Na

Synonyms

Chile saltpeter
Cubic niter
Nitrate de sodium (French)
Nitratine
Nitric acid, sodium salt
Soda niter
Sodium nitrate
Sodium saltpeter

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
Cytogenetic Analysis	oral/rat	78500 µg/kg	MUREAV 155,121,1985
Cytogenetic Analysis	oral/mouse	7067 mg/kg	MUREAV 155,121,1985
Cytogenetic Analysis	fibroblast/hamster	7200 mg/L/48H	MUREAV 48,337,1977
Cytogenetic Analysis	lung/hamster	5700 mg/L	GMCRDC 27,95,1981
host-mediated assay	embryo/hamster	125 mg/kg	MUREAV 66,149,1979
micronucleus test	oral/hamster	250 mg/kg	MUREAV 66,149,1979
micronucleus test	oral/mouse	78500 µg/kg	MUREAV 155,121,1985
morphological transform	oral/rat	13 gm/kg/6W	CRNGDP 9,387,1988
morphological transform	oral/hamster	250 mg/kg	MUREAV 66,149,1979
mutation in microorganisms	/Other microorganisms	1000 ppm (-enzymatic activation step)	POASAD 34,114,1953
phage inhibition capacity	/Escherichia coli	133 µg/well	MUREAV 260,349,1991
sperm morphology	oral/mouse	16800 mg/kg/2W	MUREAV 204,689,1988
Unscheduled DNA Synthesis	HeLa cell/human	6 mmol/L	AEMBAP 177,269,1984

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
oral/mouse	16800 mg/kg (14D male)	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)	MUREAV 204,689,1988

Tumorigenic Data and References

Route/Organism	Dose	Effect	Reference
oral/rat	lowest published toxic dose: 100 gm/kg/2Y- continuous	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Liver: Tumors	FCTOD7 22,715,1984
oral/rat	toxic dose: 1825 gm/kg/2Y- continuous	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Skin and Appendages: Tumors Reproductive: Tumorigenic effects: Testicular tumors	FCTOD7 20,25,1982
oral/rat	toxic dose: 913 gm/kg/2Y- continuous	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Skin and Appendages: Tumors Reproductive: Tumorigenic effects: Testicular tumors	FCTOD7 20,25,1982

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/Human, liver tumor	Inhibitor Concentration (50 percent kill): 125 mmol/L/24H	In Vitro Toxicity Studies: Cell protein synthesis	TIVIEQ 3,189,1989
intraperitoneal/rat	Lethal dose: >181 mg/kg		TXAPA9 5,750,1963
intravenous/mouse	lethal dose (50 percent kill): 175 mg/kg		ATXKA8 21,89,1965
oral/child	lowest published lethal dose: 22500 µg/kg	Blood: Methemoglobinemia- Carboxhemoglobinemia	JTCTDW 32,173,1994
oral/mouse	lethal dose (50 percent kill): 3500 mg/kg		VCVN5* -,49,1993
oral/pig	lowest published toxic dose: 0.5 gm/kg	Behavioral: Change in psychophysiological tests Behavioral: Food intake (animal) Blood: Methemoglobinemia- Carboxhemoglobinemia	GISAAA -,30,1993
oral/rabbit	lethal dose (50 percent kill): 2680 mg/kg		SOVEA7 27,246,1974
oral/rat	lethal dose (50 percent kill): 1267 mg/kg		GISAAA 46(12),66,1981
oral/rat	lowest published toxic dose: 1600 mg/kg	Blood: Methemoglobinemia- Carboxhemoglobinemia	TOVEFN (5),22,1996
oral/woman	lowest published toxic dose: 14 mg/kg	Cardiac: Pulse rate increased without fall in BP Lung, Thorax, or Respiration: Cyanosis Blood: Methemoglobinemia- Carboxhemoglobinemia	JTCTDW 32,173,1994

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
oral/pig	lowest published toxic dose: 3.5 gm/kg/1W- continuous	Blood: Methemoglobinemia- Carboxhemoglobinemia	GISAAA -,30,1993
oral/pig	lowest published toxic dose: 28 gm/kg/8W- continuous	Gastrointestinal: Gastritis	GISAAA -,30,1993
oral/rat	lowest published toxic dose: 1224 mg/kg/30D- intermittent	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases	VCVN5* -,50,1989
oral/rat	lowest published toxic dose: 3000 mg/kg/60D- intermittent	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects	FCTOD7 48,572,2010
oral/rat	lowest published toxic dose: 6000 mg/kg/60D- intermittent	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects Related to Chronic Data: Changes in testicular weight	FCTOD7 48,572,2010
oral/rat	lowest published toxic dose: 118 gm/kg/39W- continuous	Liver: Changes in liver weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)	TOLED5 17,125,1983
oral/rat	lowest published toxic dose: 386 gm/kg/61W- continuous	Lung, Thorax, or Respiration: Changes in lung weight Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	TOLED5 6,199,1980

Reviews

Organization	Standard	Reference
TOXICOLOGY REVIEW		TXAPA9 243,180,2010
TOXICOLOGY REVIEW		MUREAV 721,27,2011

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION		FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	RED Completed	RBREV* -,318,1998
Occupational Exposure Limit-RUSSIA	short term exposure limit 5 mg/m³, JUN2003

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Occupational Exposure Survey 1983	Hazard Code 69220; Number of Industries 249; Total Number of Facilities 40765; Number of Occupations 152; Total Number of Employees Exposed 557740; Total Number of Female Employees Exposed 110040
National Occupational Hazard Survey 1974	Hazard Code 69220; Number of Industries 164; Total Number of Facilities 17916; Number of Occupations 119; Total Number of Employees Exposed 165980

Status in Federal Agencies

Organization	Reference
EPA GENETOX PROGRAM 1988, Inconclusive: SHE-clonal assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

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Page last reviewed:March 7, 2014
Page last updated:February 6, 2017
Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division

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