Sodium bicarbonate (1:1)

RTECS #
VZ0950000
CAS #
144-55-8
See: NMAM or OSHA Methods
Updated
December 2018
Molecular Weight
84.01
Molecular Formula
CHO3·Na
Synonyms
Baking soda
Bicarbonate of soda
Carbonic acid monosodium salt
Col-evac
Jusonin
Monosodium carbonate
NEUT
Soda mint
Sodium acid carbonate
Sodium hydrogen carbonate

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mg/30S mildTXCYAC 23,281,1982
skin /human 30 mg/3D- intermittent mild85DKA8 -,127,1977

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Unscheduled DNA Synthesisoral/rat50400 mg/kg/4W-continuousCRNGDP 9,1203,1988

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse 40 mg/kg (7D pregnant)Reproductive: Other developmental abnormalitiesPOASAD 56,10,1976

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 102 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
In Vitro/Mouse, fibroblast Inhibitor Concentration (50 percent kill): 93.1 mmol/L/48HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 27,1357,2013
In Vitro/paaInhibitor Concentration Low: 85.2 mmol/L/44HIn Vitro Toxicity Studies: Other assaysTIVIEQ 27,1416,2013
inhalation/rat Lethal concentration: >900 mg/m3GTPZAB 33(5),30,1989
oral/infant lowest published toxic dose: 1260 mg/kgLung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Urine volume increased

Nutritional and Gross Metabolic: Changes in: Na
AJDCAI 135,965,1981
oral/man lowest published toxic dose: 20 mg/kg/5D- intermittentGastrointestinal: Nausea or vomiting

Nutritional and Gross Metabolic: Changes in: K

Nutritional and Gross Metabolic: Changes in: Metabolic acidosis
AJEMEN 12,57,1994
oral/mouse lethal dose (50 percent kill): 3360 mg/kgGTPZAB 33(5),30,1989
oral/rat lethal dose (50 percent kill): 4220 mg/kgTXAPA9 6,726,1964

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 77200 µg/kg/17WCardiac: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Changes in: Na
GTPZAB 33(5),30,1989
oral/domestic bird lowest published toxic dose: 17500 mg/kg/35D- continuousBlood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Changes in: Cl

Nutritional and Gross Metabolic: Changes in: K
DCTODJ 28,245,2005
oral/domestic bird lowest published toxic dose: 65625 mg/kg/35D- continuousKidney, Ureter, and Bladder: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
DCTODJ 28,245,2005
oral/domestic bird lowest published toxic dose: 175000 mg/kg/35D- continuousBehavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal)

Behavioral: Fluid intake
DCTODJ 28,245,2005
oral/domestic bird lowest published toxic dose: 175000 mg/kg/35D- continuousCardiac: Cardiomyopathy including infarction

Cardiac: Other changes

Lung, Thorax, or Respiration: Other changes
DCTODJ 28,245,2005
oral/domestic bird lowest published toxic dose: 175000 mg/kg/35D- continuousLiver: Other changes

Kidney, Ureter, and Bladder: Changes in blood vessels or in circulation of kidney

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli
DCTODJ 28,245,2005
oral/domestic bird lowest published toxic dose: 175000 mg/kg/35D- continuousMusculoskeletal: Joints

Musculoskeletal: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
DCTODJ 28,245,2005
oral/domestic bird lowest published toxic dose: 350000 mg/kg/35D- continuousKidney, Ureter, and Bladder: Structural or functional change in ureter

Kidney, Ureter, and Bladder: Changes in kidney weight

Blood: Changes in spleen
DCTODJ 28,245,2005
oral/domestic bird lowest published toxic dose: 350000 mg/kg/35D- continuousGastrointestinal: Other changesDCTODJ 28,245,2005
oral/mouse lowest published toxic dose: 907 gm/kg/30D- continuousTumorigenic: Protects against induction of experimental tumorsCNREA8 69,2260,2009
oral/mouse lowest published toxic dose: 105.9 gm/kg/35D- continuousTumorigenic: Protects against induction of experimental tumorsCNREA8 69,2260,2009

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWJRPMAP 12,27,1974
TOXICOLOGY REVIEWBPCEM* 17,237,2003
TOXICOLOGY REVIEWENTOX* -,60,2005
TOXICOLOGY REVIEWBPRCG* 21,849,2007
TOXICOLOGY REVIEWRTOPDW 58,395,2010

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X9090; Number of Industries 1; Total Number of Facilities 38; Number of Occupations 4; Total Number of Employees Exposed 1325; Total Number of Female Employees Exposed 1035
National Occupational Exposure Survey 1983Hazard Code 80069; Number of Industries 206; Total Number of Facilities 30686; Number of Occupations 169; Total Number of Employees Exposed 881879; Total Number of Female Employees Exposed 416265
National Occupational Hazard Survey 1974Hazard Code 80069; Number of Industries 158; Total Number of Facilities 27050; Number of Occupations 111; Total Number of Employees Exposed 236575

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
Page last reviewed: November 16, 2018