Sodium carbonate (2:1)
RTECS #
VZ4050000
CAS #
Updated
June 2018
Molecular Weight
105.99
Molecular Formula
CO3·2Na
Synonyms
Bisodium carbonate
Calcined soda
Carbonic acid, disodium salt
Crystol carbonate
Disodium carbonate
Snowlite 1
Soda ash
Sodium carbonate
Solvay soda
Calcined soda
Carbonic acid, disodium salt
Crystol carbonate
Disodium carbonate
Snowlite 1
Soda ash
Sodium carbonate
Solvay soda
Skin and Eye Irritation and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
eye /rabbit | 100 mg/24H | moderate | 28ZPAK -,8,1972 |
eye /rabbit | 100 mg/30S rinse | mild | TXCYAC 23,281,1982 |
eye /rabbit | 50 mg | severe | GTPZAB 20(11),55,1976 |
skin /rabbit | 500 mg/24H | mild | 28ZPAK -,7,1972 |
Reproductive Effects Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
intrauterine/mouse | 84800 ng/kg (4D pregnant) | Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) | JRPFA4 63,365,1981 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
eye/rabbit | lowest published toxic dose: 25 mg/kg | Behavioral: Muscle contraction or spasticity Lung, Thorax, or Respiration: Cyanosis | VCVN1* -,38,1998 |
In Vitro/Human, kidney | Inhibitor Concentration (20 percent kill): >100 µmol/L/2H | In Vitro Toxicity Studies: Cell metabolic activity: Alamar Blue assay etc. | TIVIEQ 40,66,2017 |
In Vitro/Human, kidney | Inhibitor Concentration (20 percent kill): >100 µmol/L/2H | Endocrine: Other changes | TIVIEQ 40,66,2017 |
In Vitro/Human, liver tumor | Inhibitor Concentration (50 percent kill): 16 mmol/L/24H | In Vitro Toxicity Studies: Cell protein synthesis | TIVIEQ 3,189,1989 |
inhalation/guinea pig | lethal concentration (50 percent kill): 800 mg/m3/2H | Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Other changes | ENVRAL 31,138,1983 |
inhalation/human | lowest published toxic concentration: 40 mg/m3/1M | Eye: Lacrimation Eye: Conjunctiva irritation | VCVN1* -,38,1998 |
inhalation/mammal (species unspecified) | lowest published toxic concentration: 100 mg/m3/4H | Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Cough | VCVN1* -,38,1998 |
inhalation/mouse | lethal concentration (50 percent kill): 1200 mg/m3/2H | Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Other changes | ENVRAL 31,138,1983 |
inhalation/rat | lethal concentration (50 percent kill): 2300 mg/m3/2H | Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Other changes | ENVRAL 31,138,1983 |
intraperitoneal/mouse | lethal dose (50 percent kill): 117 mg/kg | COREAF 257,791,1963 | |
oral/man | lowest published lethal dose: 714 mg/kg | Behavioral: General anesthetic Gastrointestinal: Ulceration or bleeding from small intestine Gastrointestinal: Other changes | YAKUD5 32,570,1990 |
oral/mouse | lethal dose (50 percent kill): 6600 mg/kg | GTPZAB 20(11),55,1976 | |
oral/mouse | lethal dose (50 percent kill): 6600 mg/kg | Olfaction: Change in sensation of smell Lung, Thorax, or Respiration: Dyspnea | VCVN1* -,37,1998 |
oral/rat | lethal dose (50 percent kill): 4090 mg/kg | 28ZPAK -,8,1972 | |
subcutaneous/mouse | lethal dose (50 percent kill): 2210 mg/kg | VCVN1* -,36,1998 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/mammal (species unspecified) | lowest published toxic concentration: 16200 µg/m3/17W- intermittent | Olfaction: Change in sensation of smell Vascular: BP elevation not characterized in autonomic section Lung, Thorax, or Respiration: Respiratory depression | GTPZAB 20(11),55,1976 |
inhalation/rat | lowest published toxic concentration: 16.2 mg/m3/16W- intermittent | Olfaction: Change in sensation of smell Lung, Thorax, or Respiration: Emphysema Immunological Including Allergic: Decrease in cellular immune response | VCVN1* -,38,1998 |
Reviews
Organization | Standard | Reference |
---|---|---|
TOXICOLOGY REVIEW | HUTOX* -,683,1996 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 | |
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES | Unsupported | RBREV* -,326,1998 |
NIOSH Documentation and Surveillance
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health