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Registry of Toxic Effects of Chemical Substances (RTECS)

Sodium carbonate (2:1)

RTECS #

VZ4050000

CAS #

497-19-8; 1332-57-6

Updated

July 2011

Molecular Weight

105.99

Molecular Formula

CO₃·2Na

Synonyms

Bisodium carbonate
Calcined soda
Carbonic acid, disodium salt
Crystol carbonate
Disodium carbonate
Snowlite 1
Soda ash
Sodium carbonate
Solvay soda

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /rabbit	100 mg/24H	moderate	28ZPAK -,8,1972
eye /rabbit	100 mg/30S rinse	mild	TXCYAC 23,281,1982
eye /rabbit	50 mg	severe	GTPZAB 20(11),55,1976
skin /rabbit	500 mg/24H	mild	28ZPAK -,7,1972

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
intrauterine/mouse	84800 ng/kg (4D pregnant)	Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)	JRPFA4 63,365,1981

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
eye/rabbit	lowest published toxic dose: 25 mg/kg	Behavioral: Muscle contraction or spasticity Lung, Thorax, or Respiration: Cyanosis	VCVN1* -,38,1998
In Vitro/Human, liver tumor	Inhibitor Concentration (50 percent kill): 16 mmol/L/24H	In Vitro Toxicity Studies: Cell protein synthesis	TIVIEQ 3,189,1989
inhalation/guinea pig	lethal concentration (50 percent kill): 800 mg/m³/2H	Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Other changes	ENVRAL 31,138,1983
inhalation/human	lowest published toxic concentration: 40 mg/m³/1M	Eye: Lacrimation Eye: Conjunctiva irritation	VCVN1* -,38,1998
inhalation/mammal (species unspecified)	lowest published toxic concentration: 100 mg/m³/4H	Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Cough	VCVN1* -,38,1998
inhalation/mouse	lethal concentration (50 percent kill): 1200 mg/m³/2H	Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Other changes	ENVRAL 31,138,1983
inhalation/rat	lethal concentration (50 percent kill): 2300 mg/m³/2H	Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Other changes	ENVRAL 31,138,1983
intraperitoneal/mouse	lethal dose (50 percent kill): 117 mg/kg		COREAF 257,791,1963
oral/man	lowest published lethal dose: 714 mg/kg	Behavioral: General anesthetic Gastrointestinal: Ulceration or bleeding from small intestine Gastrointestinal: Other changes	YAKUD5 32,570,1990
oral/mouse	lethal dose (50 percent kill): 6600 mg/kg		GTPZAB 20(11),55,1976
oral/mouse	lethal dose (50 percent kill): 6600 mg/kg	Olfaction: Change in sensation of smell Lung, Thorax, or Respiration: Dyspnea	VCVN1* -,37,1998
oral/rat	lethal dose (50 percent kill): 4090 mg/kg		28ZPAK -,8,1972
subcutaneous/mouse	lethal dose (50 percent kill): 2210 mg/kg		VCVN1* -,36,1998

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/mammal (species unspecified)	lowest published toxic concentration: 16200 µg/m³/17W- intermittent	Olfaction: Change in sensation of smell Vascular: BP elevation not characterized in autonomic section Lung, Thorax, or Respiration: Respiratory depression	GTPZAB 20(11),55,1976
inhalation/rat	lowest published toxic concentration: 16.2 mg/m³/16W- intermittent	Olfaction: Change in sensation of smell Lung, Thorax, or Respiration: Emphysema Immunological Including Allergic: Decrease in cellular immune response	VCVN1* -,38,1998

Reviews

Organization	Standard	Reference
TOXICOLOGY REVIEW		HUTOX* -,683,1996

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION		FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	Unsupported	RBREV* -,326,1998

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Occupational Exposure Survey 1983	Hazard Code 68850; Number of Industries 385; Total Number of Facilities 97764; Number of Occupations 220; Total Number of Employees Exposed 2001842; Total Number of Female Employees Exposed 761463
National Occupational Hazard Survey 1974	Hazard Code 68850; Number of Industries 389; Total Number of Facilities 148455; Number of Occupations 193; Total Number of Employees Exposed 1143671

Status in Federal Agencies

Organization	Reference
EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

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Page last reviewed:March 7, 2014
Page last updated:February 6, 2017
Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division

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